Neuromuscular and biomechanical mechanisms associated with PFM function in humans
与人类 PFM 功能相关的神经肌肉和生物力学机制
基本信息
- 批准号:RGPIN-2016-05256
- 负责人:
- 金额:$ 2.99万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The long term objective of my research program is to understand the normal function of the pelvic floor muscles (PFMs) in terms of their contributions to continence function, sexual function, pelvic organ support, and postural control in both women and men. Despite their obvious and important roles in each of these systems, the normative function of the PFMs is poorly understood. In part, this knowledge gap is related to the limited availability of tools and techniques because the physiological and mechanical properties of the PFMs cannot be studied using traditional electromyographic, kinematic and kinetic approaches. Further, the PFMs are involved in multiple functions, and, at times, have competing demands for contraction and relaxation.*******To date, my research has followed three distinct, but complementary pathways to the achieve my long-term objective. These are: (1) the development of novel measurement tools and techniques to study PFM function, (2) understanding the neuromuscular control of the PFMs in the context of their need to support multiple systems, and (3) understanding the biomechanical properties of the PFMs and how these relate to their role within different human systems . Over the past five years, we have made significant gains in all of these areas, and my proposed research program will build on these achievements under the same general pathways:*******(1) Novel tools and techniques: (i) we will complete in-vivo testing of a new intravaginal dynamometer designed to measure PFM contractile force and passive stiffness properties, (ii) we will automate our sagittal plane ultrasound image analysis to study urethral kinematics and kinetics during dynamic tasks, (iii) We will develop and evaluate shear wave elastography methods to measure PFM tissue stiffness in-vivo. We will evaluate how these properties relate to active and passive tissue properties measured using our vaginal dynamometer.****(2) PFM neuromuscular control: We will use dual and higher order task paradigms to investigate the ways in which the PFMs and their synergists respond to concurrent challenges. We will investigate how the human systems prioritize PFM activation and the effect of age on PFM function in this context. Finally, we will investigate proprioceptive sensation from the PFMs and investigate the relationship between proprioceptive outcomes and capacity for PFM activation.****(3) PFM biomechanics: We will build a normative dataset to investigate the biomechanical properties of the PFMs in vivo and will study how these properties change with age.****This work will culminate in a clear understanding of the motor control and biomechanics of PFM function in women, with the view to understanding how the PFMs simultaneously support continence and motor functions. This work will pave the way to follow-on steps including the study of sex differences in pelvic floor structure and function and the role of the PFMs in sexual function.***
我的研究计划的长期目标是了解盆底肌肉(PFM)的正常功能,即它们对女性和男性的控制功能、性功能、盆腔器官支持和姿势控制的贡献。尽管它们在每一个系统中都发挥着明显而重要的作用,但对全要素管理的规范职能却知之甚少。在一定程度上,这种知识差距与可用工具和技术的有限有关,因为无法使用传统的肌电图学、运动学和动力学方法来研究PFM的生理和机械特性。此外,全氟甲烷涉及多种功能,有时对收缩和放松有相互竞争的需求。到目前为止,我的研究遵循了三条截然不同但相辅相成的途径来实现我的长期目标。这些是:(1)研究PFM功能的新的测量工具和技术的发展;(2)在需要支持多个系统的背景下了解PFM的神经肌肉控制;(3)了解PFM的生物力学特性以及这些特性与它们在不同人体系统中的作用之间的关系。在过去的五年里,我们在所有这些领域都取得了重大进展,我提出的研究计划将在相同的一般路径下以这些成就为基础:*(1)新的工具和技术:(I)我们将完成一种新型阴道内测力仪的体内测试,该测力仪旨在测量PFM的收缩力和被动硬度特性;(Ii)我们将自动化我们的矢状面超声图像分析,以研究动态任务期间的尿路运动学和动力学;(Iii)我们将开发和评估剪切波弹性成像方法,以在体内测量PFM组织硬度。我们将评估这些特性与使用我们的阴道测力仪测量的主动和被动组织特性之间的关系。*(2)PFM神经肌肉控制:我们将使用双重和更高阶的任务范式来研究PFM及其增效剂应对并发挑战的方式。在此背景下,我们将研究人类系统如何优先考虑PFM的激活以及年龄对PFM功能的影响。最后,我们将研究PFM的本体感觉和PFM激活能力之间的关系。*(3)PFM生物力学:我们将建立一个标准化的数据集来研究体内PFM的生物力学特性,并研究这些特性如何随年龄变化。*这项工作最终将使我们清楚地了解PFM功能的运动控制和生物力学,以期了解PFM如何同时支持可控性和运动功能。这项工作将为后续步骤铺平道路,包括研究盆底结构和功能的性别差异以及PFM在性功能中的作用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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McLean, Linda其他文献
Assessing motor deficits in compressive neuropathy using quantitative electromyography
- DOI:
10.1186/1743-0003-7-39 - 发表时间:
2010-08-11 - 期刊:
- 影响因子:5.1
- 作者:
Nashed, Joseph;Hamilton-Wright, Andrew;McLean, Linda - 通讯作者:
McLean, Linda
The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: aerobic exercise programs
- DOI:
10.1177/0269215517691085 - 发表时间:
2017-05-01 - 期刊:
- 影响因子:3
- 作者:
Brosseau, Lucie;Taki, Jade;McLean, Linda - 通讯作者:
McLean, Linda
Insight into the function of the obturator internus muscle in humans: Observations with development and validation of an electromyography recording technique
- DOI:
10.1016/j.jelekin.2014.03.011 - 发表时间:
2014-08-01 - 期刊:
- 影响因子:2.5
- 作者:
Hodges, Paul W.;McLean, Linda;Hodder, Joanne - 通讯作者:
Hodder, Joanne
The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part two: strengthening exercise programs
- DOI:
10.1177/0269215517691084 - 发表时间:
2017-05-01 - 期刊:
- 影响因子:3
- 作者:
Brosseau, Lucie;Taki, Jade;McLean, Linda - 通讯作者:
McLean, Linda
Selective recruitment of the lower fibers of the trapezius muscle
- DOI:
10.1016/j.jelekin.2010.11.006 - 发表时间:
2011-06-01 - 期刊:
- 影响因子:2.5
- 作者:
Arlotta, Melissa;LoVasco, Gina;McLean, Linda - 通讯作者:
McLean, Linda
McLean, Linda的其他文献
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{{ truncateString('McLean, Linda', 18)}}的其他基金
Neuromuscular and biomechanical mechanisms associated with PFM function in humans
与人类 PFM 功能相关的神经肌肉和生物力学机制
- 批准号:
RGPIN-2016-05256 - 财政年份:2021
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Neuromuscular and biomechanical mechanisms associated with PFM function in humans
与人类 PFM 功能相关的神经肌肉和生物力学机制
- 批准号:
RGPIN-2016-05256 - 财政年份:2020
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Neuromuscular and biomechanical mechanisms associated with PFM function in humans
与人类 PFM 功能相关的神经肌肉和生物力学机制
- 批准号:
RGPIN-2016-05256 - 财政年份:2017
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Neuromuscular and biomechanical mechanisms associated with PFM function in humans
与人类 PFM 功能相关的神经肌肉和生物力学机制
- 批准号:
RGPIN-2016-05256 - 财政年份:2016
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Quantitative shear-wave elastography and dynamic ultasound imaging for human biomechanics research
用于人体生物力学研究的定量剪切波弹性成像和动态超声成像
- 批准号:
RTI-2017-00098 - 财政年份:2016
- 资助金额:
$ 2.99万 - 项目类别:
Research Tools and Instruments
Ultrasound imaging to evaluate the biomechanics of the female pelvic floor
超声成像评估女性盆底生物力学
- 批准号:
217361-2009 - 财政年份:2014
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Ultrasound imaging to evaluate the biomechanics of the female pelvic floor
超声成像评估女性盆底生物力学
- 批准号:
217361-2009 - 财政年份:2012
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Ultrasound imaging to evaluate the biomechanics of the female pelvic floor
超声成像评估女性盆底生物力学
- 批准号:
217361-2009 - 财政年份:2011
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Ultrasound imaging to evaluate the biomechanics of the female pelvic floor
超声成像评估女性盆底生物力学
- 批准号:
217361-2009 - 财政年份:2010
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
Ultrasound imaging to evaluate the biomechanics of the female pelvic floor
超声成像评估女性盆底生物力学
- 批准号:
217361-2009 - 财政年份:2009
- 资助金额:
$ 2.99万 - 项目类别:
Discovery Grants Program - Individual
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