Improving signal to Noise Ratio and decoupling surface and bulk effects in Nicoya's Open surface Plasmin Resonance (SPR) systems

提高 Nicoya 开放表面纤溶酶共振 (SPR) 系统中的信噪比并消除表面和体效应

• 批准号: 522337-2018
• 负责人: Mojahedi, Mohammad
• 金额: $ 1.82万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=660023
• 关键词: Improving; signal; Noise; Ratio; decoupling

The current application brings together Nicoya Life Sciences, an original manufacturer of Surface Plasmon Resonance (SPR)**sensing systems located at Waterloo/Kitchener area, and Prof. Mo Mojahedis team at the University of Toronto (UofT). Professor**Mojahedi leads an internationally renowned group with expertise in design and characterization of optical/plasmonic sensing**modalities.**The goals of the current project are: (a) to improve the signal to noise ratio (S/N) of the existing and next generation Nicoyas**SPR systems. (b) To introduce a technology developed by Mojahedis group known as multimode spectroscopy in the design**of Nicoyas next generation SPR systems. The increased S/N will allow Nicoya to improve its systems resolution (the smallest**amount of change in the input that can be detected at the sensors output) by multiple factors, while the multimode spectroscopy**will provide Nicoya with unprecedented ability to decouple and remove the interfering surface and bulk effects. The**aforementioned interfering surface and bulk effects are present during operation of any affinity sensor and their presence is**detrimental to accurate determination of analyte concentrations.**Successful implementation of the objectives and Specific Aims described in this proposal will provide Nicoya with more advanced**systems; hence enabling Nicoya to compete more effectively in the current market, enhance its revenues and export opportunities,**create many additional jobs in Ontario, and provide a training opportunity for new hires via collaborating with the UofT team.**

目前的应用将位于滑铁卢/基奇纳地区的表面等离子体共振(SPR)**传感系统的原始制造商Nicoya Life Sciences和多伦多大学(UofT)的Mo Mojahedis教授团队聚集在一起。莫贾赫迪教授领导着一个在光学/等离子激元传感**模式的设计和表征方面拥有专业知识的国际知名团队。**当前项目的目标是：(A)提高现有和下一代NICOYAS**SPR系统的信噪比(S/N)。(B)将Mojahedis集团开发的称为多模光谱学的技术引入尼古拉斯下一代SPR系统的设计**。增加的S/N将允许尼科亚通过多种因素提高其系统分辨率(在传感器输出处可以检测到的输入的最小**变化量)，而多模光谱**将为尼科亚提供前所未有的去耦合和消除干扰表面和体效应的能力。**上述干扰表面和体积效应存在于任何亲和力传感器的操作过程中，它们的存在**不利于分析物浓度的准确测定。**成功实施本提案中描述的目标和特定目标将为Nicoya提供更先进的**系统；从而使Nicoya能够在当前市场更有效地竞争，提高其收入和出口机会，**在安大略省创造许多额外的就业机会，并通过与UofT团队的合作为新员工提供培训机会。**