Improving signal to Noise Ratio and decoupling surface and bulk effects in Nicoya's Open surface Plasmin Resonance (SPR) systems

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The current application brings together Nicoya Life Sciences, an original manufacturer of Surface Plasmon Resonance (SPR)**sensing systems located at Waterloo/Kitchener area, and Prof. Mo Mojahedis team at the University of Toronto (UofT). Professor**Mojahedi leads an internationally renowned group with expertise in design and characterization of optical/plasmonic sensing**modalities.**The goals of the current project are: (a) to improve the signal to noise ratio (S/N) of the existing and next generation Nicoyas**SPR systems. (b) To introduce a technology developed by Mojahedis group known as multimode spectroscopy in the design**of Nicoyas next generation SPR systems. The increased S/N will allow Nicoya to improve its systems resolution (the smallest**amount of change in the input that can be detected at the sensors output) by multiple factors, while the multimode spectroscopy**will provide Nicoya with unprecedented ability to decouple and remove the interfering surface and bulk effects. The**aforementioned interfering surface and bulk effects are present during operation of any affinity sensor and their presence is**detrimental to accurate determination of analyte concentrations.**Successful implementation of the objectives and Specific Aims described in this proposal will provide Nicoya with more advanced**systems; hence enabling Nicoya to compete more effectively in the current market, enhance its revenues and export opportunities,**create many additional jobs in Ontario, and provide a training opportunity for new hires via collaborating with the UofT team.**