Discovery of chemical compounds with high aging-delaying, health-improving and lifespan-extending efficiencies and characterization of their action mechanisms

具有高延缓衰老、改善健康和延长寿命功效的化合物的发现及其作用机制的表征

• 批准号: 515900-2017
• 负责人: Titorenko, Vladimir
• 金额: $ 2.55万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=666878
• 关键词: Discovery; chemical; compounds; aging; delaying

Using funding provided by the NSERC Engage and Engage Plus grants, we have screened a library of plant**extracts (PEs) for extracts that can delay chronological aging of the yeast Saccharomyces cerevisiae. The**library was provided by Idunn Technologies Inc., a company in the Montreal area. Our initial screen has**revealed 6 PEs that increase yeast chronological lifespan to a significantly greater extent than any of the**presently known longevity-extending chemical compounds. We demonstrated that each of the 6 initially**discovered PEs is a geroprotector which elicits a hormetic stress response, affects a distinct set of**longevity-defining cellular processes, and slows yeast chronological aging through different signaling pathways**and protein kinases that converge into an evolutionarily conserved network. Our recent screen of the library of**PEs provided by Idunn Technologies Inc. has revealed 15 other extracts that delay yeast chronological aging.**With the present research proposal, we seek the CRD Grant for the period of 3 years. The proposed here CRD**project will: 1) identify chemical compounds responsible for the delay of aging by each of the 21 PEs we**discovered; 2) assess how the 15 recently discovered aging-delaying PEs influence a distinct set of**longevity-defining cellular processes; 3) investigate how the 15 recently discovered aging-delaying plant**extracts impact a longevity-defining network of signaling pathways and protein kinases; and 4) examine if**some combinations of the 21 PEs may have additive or synergistic effects on the aging-delaying efficiencies of**each other. The proposed here research project will: 1) advance current understanding of mechanisms**underlying the complexity of biological aging; 2) stimulate professional development of two graduate students;**3) enable to develop new formulations of natural health products with the maximal aging-delaying and**lifespan-extending effects; 4) give Idunn Technologies Inc. access to the unique knowledge, expertise and**educational resources available in our laboratory at Concordia University; and 5) have a major beneficial**impact on the commercial success of Idunn Technologies Inc.

利用NSERC Engage and Engage Plus赠款提供的资金，我们筛选了一个植物**提取物(PE)文库，以寻找可以延缓酿酒酵母时间老化的提取物。**图书馆由蒙特利尔地区的一家公司Idunn Technologies Inc.提供。我们的初步筛选**揭示了6种PE，它们比目前已知的任何**延长寿命的化合物都能显著延长酵母的实际寿命。我们证明了最初发现的6种PE中的每一种都是一种GeroProtector，可以引起节律应激反应，影响一组独特的决定长寿的细胞过程，并通过不同的信号通路**和汇聚到进化保守网络中的蛋白激酶来减缓酵母的时间衰老。我们最近对Idunn Technologies Inc.提供的**PE库进行了筛选，发现了其他15种可延缓酵母时间老化的提取物。**根据目前的研究提案，我们申请为期3年的CRD补助金。拟议的HERE CRD**项目将：1)确定我们**发现的21个PE中每一个对延缓衰老负责的化合物；2)评估最近发现的15个延缓衰老的PE如何影响一组独特的**定义长寿的细胞过程；3)调查最近发现的15种延缓衰老的植物**提取物如何影响定义长寿的信号通路和蛋白激酶网络；以及4)检查**这21个PE的**某些组合是否对**彼此的延缓衰老效率具有相加或协同作用。这里提出的研究项目将：1)促进当前对生物衰老复杂性机制**的理解；2)刺激两名研究生的专业发展；**3)能够开发出具有最大延缓衰老和**延长寿命效果的天然保健品的新配方；4)使Idunn Technologies Inc.能够获得我们位于康科迪亚大学的实验室提供的独特知识、专业知识和**教育资源；以及5)对Idunn Technologies Inc.的商业成功产生重大有益的**影响。