Discovery of chemical compounds with high aging-delaying, health-improving and lifespan-extending efficiencies and characterization of their action mechanisms

具有高延缓衰老、改善健康和延长寿命功效的化合物的发现及其作用机制的表征

• 批准号: 515900-2017
• 负责人: Titorenko, Vladimir
• 金额: $ 2.54万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696918
• 关键词: Discovery; chemical; compounds; aging; delaying

Using funding provided by the NSERC Engage and Engage Plus grants, we have screened a library of plant extracts (PEs) for extracts that can delay chronological aging of the yeast Saccharomyces cerevisiae. The library was provided by Idunn Technologies Inc., a company in the Montreal area. Our initial screen has revealed 6 PEs that increase yeast chronological lifespan to a significantly greater extent than any of the presently known longevity-extending chemical compounds. We demonstrated that each of the 6 initially discovered PEs is a geroprotector which elicits a hormetic stress response, affects a distinct set of longevity-defining cellular processes, and slows yeast chronological aging through different signaling pathways and protein kinases that converge into an evolutionarily conserved network. Our recent screen of the library of PEs provided by Idunn Technologies Inc. has revealed 15 other extracts that delay yeast chronological aging. With the present research proposal, we seek the CRD Grant for the period of 3 years. The proposed here CRD project will: 1) identify chemical compounds responsible for the delay of aging by each of the 21 PEs we discovered; 2) assess how the 15 recently discovered aging-delaying PEs influence a distinct set of longevity-defining cellular processes; 3) investigate how the 15 recently discovered aging-delaying plant extracts impact a longevity-defining network of signaling pathways and protein kinases; and 4) examine if some combinations of the 21 PEs may have additive or synergistic effects on the aging-delaying efficiencies of each other. The proposed here research project will: 1) advance current understanding of mechanisms underlying the complexity of biological aging; 2) stimulate professional development of two graduate students; 3) enable to develop new formulations of natural health products with the maximal aging-delaying and lifespan-extending effects; 4) give Idunn Technologies Inc. access to the unique knowledge, expertise and educational resources available in our laboratory at Concordia University; and 5) have a major beneficial impact on the commercial success of Idunn Technologies Inc.

利用NSERC Engage和Engage Plus赠款提供的资金，我们筛选了一个植物库， 提取物（PE）的提取物，可以延缓老化的酵母酿酒酵母。的 文库由Idunn Technologies Inc.提供，蒙特利尔地区的一家公司。我们的初始屏幕 揭示了6个PE，增加酵母的时间寿命，以显着更大的程度比任何 目前已知的长寿化合物。我们证明了这六个人中的每一个 发现PE是一种老年保护剂，可以激发兴奋性应激反应，影响一组独特的 决定寿命的细胞过程，并通过不同的信号通路减缓酵母的按时间顺序老化 和蛋白质激酶汇聚成进化上保守的网络。我们最近的屏幕的图书馆 由Idunn Technologies Inc.提供的PE。揭示了其他15种提取物，延缓酵母的时间老化。 就目前的研究建议，我们寻求为期三年的CRD补助金。此处建议的CRD 该项目将：1）确定化学化合物负责延迟老化的21个PE，我们 2）评估15种最近发现的延缓衰老的PE如何影响一组不同的 3）研究最近发现的15种延缓衰老的植物 提取物影响信号通路和蛋白激酶的长寿定义网络;以及4）检查 21种PE的某些组合可能对以下物质的老化延迟效率具有相加或协同效应： 对方.本研究的目的是：1）促进对现有机制的理解 2）激发两名研究生的专业发展; 3)能够开发出最大限度延缓衰老的天然保健品新剂型， 延长寿命的效果; 4）给Idunn Technologies Inc.获得独特的知识，专业知识和 教育资源可在我们的实验室在康考迪亚大学;和5）有一个主要的有益 对Idunn Technologies Inc.商业成功的影响