Discovery of chemical compounds with high aging-delaying, health-improving and lifespan-extending efficiencies and characterization of their action mechanisms
具有高延缓衰老、改善健康和延长寿命功效的化合物的发现及其作用机制的表征
基本信息
- 批准号:515900-2017
- 负责人:
- 金额:$ 2.54万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Collaborative Research and Development Grants
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Using funding provided by the NSERC Engage and Engage Plus grants, we have screened a library of plantextracts (PEs) for extracts that can delay chronological aging of the yeast Saccharomyces cerevisiae. Thelibrary was provided by Idunn Technologies Inc., a company in the Montreal area. Our initial screen hasrevealed 6 PEs that increase yeast chronological lifespan to a significantly greater extent than any of thepresently known longevity-extending chemical compounds. We demonstrated that each of the 6 initiallydiscovered PEs is a geroprotector which elicits a hormetic stress response, affects a distinct set oflongevity-defining cellular processes, and slows yeast chronological aging through different signaling pathwaysand protein kinases that converge into an evolutionarily conserved network. Our recent screen of the library ofPEs provided by Idunn Technologies Inc. has revealed 15 other extracts that delay yeast chronological aging.With the present research proposal, we seek the CRD Grant for the period of 3 years. The proposed here CRDproject will: 1) identify chemical compounds responsible for the delay of aging by each of the 21 PEs wediscovered; 2) assess how the 15 recently discovered aging-delaying PEs influence a distinct set oflongevity-defining cellular processes; 3) investigate how the 15 recently discovered aging-delaying plantextracts impact a longevity-defining network of signaling pathways and protein kinases; and 4) examine ifsome combinations of the 21 PEs may have additive or synergistic effects on the aging-delaying efficiencies ofeach other. The proposed here research project will: 1) advance current understanding of mechanismsunderlying the complexity of biological aging; 2) stimulate professional development of two graduate students;3) enable to develop new formulations of natural health products with the maximal aging-delaying andlifespan-extending effects; 4) give Idunn Technologies Inc. access to the unique knowledge, expertise andeducational resources available in our laboratory at Concordia University; and 5) have a major beneficialimpact on the commercial success of Idunn Technologies Inc.
利用NSERC Engage和Engage Plus赠款提供的资金,我们筛选了一个植物提取物(PE)库,以获得可以延迟酿酒酵母(Saccharomyces cerevisiae)老化的提取物。该软件由Idunn Technologies Inc.提供,蒙特利尔地区的一家公司。我们的初步筛选揭示了6种PE,它们比目前已知的任何延长寿命的化合物都能显著提高酵母的时间寿命。我们证明了最初发现的6种PE中的每一种都是一种老年保护剂,它能激发激素应激反应,影响一组独特的定义长寿的细胞过程,并通过不同的信号通路和蛋白激酶减缓酵母的时间老化,这些信号通路和蛋白激酶汇聚成一个进化上保守的网络。我们最近筛选了Idunn Technologies Inc.提供的PE库。已经揭示了15种其他提取物,延缓酵母的时间老化。与目前的研究建议,我们寻求CRD赠款为期3年。本文提出的CRD项目将:1)确定我们发现的21种PE中的每一种都负责延缓衰老的化合物; 2)评估最近发现的15种延缓衰老的PE如何影响一组独特的决定长寿的细胞过程; 3)研究最近发现的15种延缓衰老的植物提取物如何影响决定长寿的信号通路和蛋白激酶网络;(4)考察21种PE的某些组合是否对彼此的延缓衰老效果具有相加或协同作用。本研究计划将:1)推进目前对生物衰老复杂性机制的理解; 2)促进两名研究生的专业发展;3)开发具有最大延缓衰老和延长寿命效果的天然保健品新配方; 4)为Idunn Technologies Inc.获得我们在康考迪亚大学实验室提供的独特知识,专业知识和教育资源; 5)对Idunn Technologies Inc.的商业成功产生重大影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Titorenko, Vladimir其他文献
Titorenko, Vladimir的其他文献
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{{ truncateString('Titorenko, Vladimir', 18)}}的其他基金
Discovery of chemical compounds with high aging-delaying, health-improving and lifespan-extending efficiencies and characterization of their action mechanisms
具有高延缓衰老、改善健康和延长寿命功效的化合物的发现及其作用机制的表征
- 批准号:
515900-2017 - 财政年份:2020
- 资助金额:
$ 2.54万 - 项目类别:
Collaborative Research and Development Grants
Discovery of chemical compounds with high aging-delaying, health-improving and lifespan-extending efficiencies and characterization of their action mechanisms
具有高延缓衰老、改善健康和延长寿命功效的化合物的发现及其作用机制的表征
- 批准号:
515900-2017 - 财政年份:2018
- 资助金额:
$ 2.54万 - 项目类别:
Collaborative Research and Development Grants
Mechanisms linking lipid metabolism to cellular aging in yeast
酵母中脂质代谢与细胞衰老的联系机制
- 批准号:
RGPIN-2014-04482 - 财政年份:2018
- 资助金额:
$ 2.54万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms linking lipid metabolism to cellular aging in yeast
酵母中脂质代谢与细胞衰老的联系机制
- 批准号:
RGPIN-2014-04482 - 财政年份:2017
- 资助金额:
$ 2.54万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms linking lipid metabolism to cellular aging in yeast
酵母中脂质代谢与细胞衰老的联系机制
- 批准号:
RGPIN-2014-04482 - 财政年份:2016
- 资助金额:
$ 2.54万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms linking lipid metabolism to cellular aging in yeast
酵母中脂质代谢与细胞衰老的联系机制
- 批准号:
RGPIN-2014-04482 - 财政年份:2015
- 资助金额:
$ 2.54万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms linking lipid metabolism to cellular aging in yeast
酵母中脂质代谢与细胞衰老的联系机制
- 批准号:
RGPIN-2014-04482 - 财政年份:2014
- 资助金额:
$ 2.54万 - 项目类别:
Discovery Grants Program - Individual
Continuation of the project on using an assay for yeast lifespan measurement as a robust approach for assessing the anti-aging efficiencies of numerous natural products
继续使用酵母寿命测定法作为评估多种天然产品抗衰老功效的可靠方法的项目
- 批准号:
469397-2014 - 财政年份:2014
- 资助金额:
$ 2.54万 - 项目类别:
Engage Plus Grants Program
Molecular mechanisms of peroxisome assembly
过氧化物酶体组装的分子机制
- 批准号:
283228-2009 - 财政年份:2013
- 资助金额:
$ 2.54万 - 项目类别:
Discovery Grants Program - Individual
Development and validation of an assay for yeast lifespan measurement as a robust experimental approach for assessing the anti-aging efficiencies of numerous natural products
开发和验证酵母寿命测量方法,作为评估多种天然产品抗衰老功效的可靠实验方法
- 批准号:
460925-2013 - 财政年份:2013
- 资助金额:
$ 2.54万 - 项目类别:
Engage Grants Program
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基于活性的人菱形蛋白酶蛋白质分析,用于抑制剂发现和酶表征
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Discovery of chemical compounds with high aging-delaying, health-improving and lifespan-extending efficiencies and characterization of their action mechanisms
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