Investigating the antibiotic potentiating activity of a waste product obtained during maple syrup production

研究枫糖浆生产过程中产生的废物的抗生素增强活性

• 批准号: 529846-2018
• 负责人: Tufenkji, Nathalie
• 金额: $ 1.71万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=667261
• 关键词: Investigating; antibiotic; potentiating; activity; waste

Maple drèche is a filtration residue from the production of maple syrup that is produced at a rate of 1 million pounds in Québec alone yet is commonly discarded, making it a nearly zero-added value by-product. Thus, it is of considerable interest to Canada - the leading global producer of maple syrup - to identify potential commercial applications for maple drèche. With NSERC Engage funding, Professor Nathalie Tufenkji's team at McGill University, in close collaboration with the Federation of Maple Syrup Producers of Quebec (FMSPQ), conducted a successful pilot study demonstrating that: (a) the phenolics present in drèche obtained during maple syrup production are readily extractable, and, (b) that they potentiate (boost) antibiotics. The NSERC Engage project provided critical proof-of-concept data motivating the need for further study and for the potential exploitation of maple syrup drèche phenolics in commercial applications. The general objective of the collaboration is to demonstrate the antibiotic potentiating activity of maple syrup drèche phenolics with different classes of antibiotics relevant to Canadian food animals. The research addresses a critical need to improve our ability to treat bacterial infections while reducing the use of antibiotics in food animals. Our approach involves a series of experiments using well-established microbiological and molecular assays. The project will contribute to the training of a Ph.D. student at McGill University as well as three undergraduate researchers, who will receive support from an experienced Research Associate. Determining the antibiotic potentiating activity of maple syrup drèche phenolics for different antibiotics will be of significant value to the FMSPQ. The expected outcome of this research is a better understanding of the underlying mechanisms by which drèche phenolics can provide benefits. This will enable the FMSPQ to develop new added-value products from a material that is commonly discarded. This will increase profitability for all Canadian maple syrup producers, while contributing to the control of the global spread in antibiotic resistance. **

枫糖浆是枫糖浆生产过程中的过滤残留物，仅在魁北克省就以 100 万磅的速度生产枫糖浆，但通常被丢弃，使其成为几乎零附加值的副产品。因此，加拿大——全球领先的枫糖浆生产国——对确定枫糖浆的潜在商业应用非常感兴趣。在 NSERC Engage 的资助下，麦吉尔大学 Nathalie Tufenkji 教授的团队与魁北克枫糖浆生产商联合会 (FMSPQ) 密切合作，进行了一项成功的试点研究，证明：(a) 枫糖浆生产过程中获得的 Drèche 中存在的酚类物质很容易提取，并且 (b) 它们可以增强（增强）抗生素。 NSERC Engage 项目提供了关键的概念验证数据，激发了进一步研究和枫糖浆酚醛树脂在商业应用中的潜在开发的需求。此次合作的总体目标是证明枫糖浆酚类物质与加拿大食用动物相关的不同类别抗生素的抗生素增强活性。该研究解决了提高我们治疗细菌感染的能力同时减少食用动物抗生素使用的迫切需求。我们的方法涉及使用成熟的微生物和分子检测进行一系列实验。该项目将有助于培养博士生。麦吉尔大学的学生以及三名本科研究人员，他们将得到经验丰富的研究助理的支持。确定枫糖浆酚类物质对不同抗生素的抗生素增强活性对于 FMSPQ 具有重要价值。这项研究的预期结果是更好地了解 Drèche 酚类物质提供益处的潜在机制。这将使 FMSPQ 能够利用通常被丢弃的材料开发新的增值产品。这将提高所有加拿大枫糖浆生产商的盈利能力，同时有助于控制抗生素耐药性的全球蔓延。 **