Market Assessment of Novel Nematicidal Agents to Improve Crop Production

提高作物产量的新型杀线虫剂的市场评估

• 批准号: 544493-2019
• 负责人: Roy, Peter
• 金额: $ 1.09万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=675593
• 关键词: Market; Assessment; Novel; Nematicidal; Agents

This proposal seeks to fund a market assessment of novel nematicidal agents to improve crop production. A major threat to food production everywhere is crop destruction by plant parasitic nematodes (PPNs). Globally, PPNs are estimated to cause $350 billion in crop losses every year. In some cases, PPNs reduce crop yield by over 80%. As global temperatures rise, the rate of crop infestation by PPNs will increase and additional PPN species will become new threats to Canadian agriculture. Clearly, PPNs pose a serious threat to global food security.Although sound agricultural practices, biologicals, and GMOs can reduce PPN infestation, the more than 4000 different PPN species find ways to circumvent these innovations. Small molecule nematicides have consequently been essential in PPN control strategies. Concerns over environmental toxicity and human safety have justifiably prompted restrictions and bans on many effective nematicides, including the fumigant methyl bromide, and neurotoxic organophosphates and carbamates. Regulations have limited the number of available nematicides such that there are no longer reliable control options for several PPN species, including Meloidogyne hapla that parasitizes Canadian potatoes, onion, tomatoes and other crops. There is a clear need to develop new, safe and effective chemical tools to control PPNs.The Roy Lab has developped an efficient pipeline with which to identify candidate nematicides. With this pipeline, the Roy Lab has identified 9 unique small molecule stuctures that kill PPNs effectively in laboratory tests. The group has filed provisional patents against four of these structures and is working to secure IP for the remainder. The market assessment is the first step towards securing additional I2I funding that will be key in developing these nematicide hits into bona fide marketable nematicides.

该提案旨在为新型杀线虫剂的市场评估提供资金，以提高作物产量。世界各地粮食生产的一个主要威胁是植物寄生线虫（PPN）对农作物的破坏。 在全球范围内，PPN估计每年造成3500亿美元的作物损失。在某些情况下，PPN使作物产量减少80%以上。随着全球气温的上升，PPN对作物的侵染率将增加，更多的PPN物种将成为加拿大农业的新威胁。很明显，PPN对全球粮食安全构成了严重威胁。尽管合理的农业实践、生物制剂和转基因生物可以减少PPN的侵扰，但4000多种不同的PPN物种找到了规避这些创新的方法。因此，小分子杀线虫剂在PPN控制策略中至关重要。对环境毒性和人类安全的担忧无疑促使限制和禁止许多有效的杀线虫剂，包括熏蒸剂甲基溴和神经毒性有机磷酸酯和氨基甲酸酯。法规限制了可用的杀线虫剂的数量，使得对几种PPN物种不再有可靠的控制选择，包括寄生在加拿大马铃薯、洋葱、番茄和其他作物上的北方根结线虫。显然需要开发新的、安全有效的化学工具来控制PPN。罗伊实验室已经开发了一个有效的管道来识别候选杀线虫剂。 通过这个管道，罗伊实验室已经确定了9种独特的小分子结构，可以在实验室测试中有效杀死PPN。该集团已对其中四个结构申请了临时专利，并正在努力为其余结构获得知识产权。市场评估是确保额外I2I资金的第一步，这将是将这些杀线虫剂开发成真正可销售的杀线虫剂的关键。