Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage

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Osteoarthritis is the most common form of arthritis, affecting over three million Canadians. The onset of osteoarthritis is believed to be associated with abnormal contact mechanics of articular cartilage, the thin layers of soft tissue that provide virtually friction-free gliding surfaces in a healthy joint such as knee and hip. Joint reconstruction is often performed to partially recover the mechanical function of the joint with end-stage arthritis. Advancement in joint mechanics will help uncover the mystery of arthritis and improve joint reconstruction. Recent studies also highlight the role of advanced joint mechanics in early diagnosis of arthritis using measurements from the joint. We will study joint mechanics by building a computer knee model that incorporates the most recent development in the mechanics of articular cartilage.