Pathomechanics of human diarthrodial joints - associations with the structure of collagen network in articular cartilage

人类二节关节的病理力学 - 与关节软骨中胶原蛋白网络结构的关联

• 批准号: 356517-2009
• 负责人: Li, Leping
• 金额: $ 1.75万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=504880
• 关键词: Pathomechanics; human; diarthrodial; joints; associations

Osteoarthritis is the most common form of arthritis, affecting over three million Canadians. The onset of osteoarthritis is believed to be associated with abnormal contact mechanics of articular cartilage, the thin layers of soft tissue that provide virtually friction-free gliding surfaces in a healthy joint such as knee and hip. Joint reconstruction is often performed to partially recover the mechanical function of the joint with end-stage arthritis. Advancement in joint mechanics will help uncover the mystery of arthritis and improve joint reconstruction. Recent studies also highlight the role of advanced joint mechanics in early diagnosis of arthritis using measurements from the joint. We will study joint mechanics by building a computer knee model that incorporates the most recent development in the mechanics of articular cartilage.

骨关节炎是最常见的关节炎，影响超过300万加拿大人。 骨关节炎的发作被认为与关节软骨的异常接触力学有关，关节软骨是在健康关节（例如膝关节和髋关节）中提供几乎无摩擦滑动表面的软组织薄层。 关节重建通常用于部分恢复终末期关节炎关节的机械功能。 关节力学的进步将有助于揭开关节炎的奥秘，改善关节重建。 最近的研究还强调了先进的关节力学在关节炎早期诊断中的作用。 我们将通过建立一个计算机膝关节模型来研究关节力学，该模型结合了关节软骨力学的最新发展。