Development of natural antioxidant formulation for improved Vitamin A soft gelatin capsules stability and shelf-life

开发天然抗氧化剂配方以改善维生素 A 软明胶胶囊的稳定性和保质期

• 批准号: 538071-2019
• 负责人: Marquardt, Drew
• 金额: $ 1.82万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=680505
• 关键词: Development; natural; antioxidant; formulation; improved

Catalent is one of the largest suppliers of Vitamin A palmitate capsules to Nutrition International (previously Micronutrient Initiative), which is an organization aimed at eliminating malnutrition throughout the world. Currently, the Vitamin A capsules are stabilized by the addition of vitamin E acetate. However, as this product is often distributed in harsh climates with elevated temperatures and humidity, the shelf-life is reduced compared to storage in North America. It would be a great advantage to both patients and providers if a more stable lipid-based system with a longer shelf life could be developed. This project proposes to develop and implement a novel antioxidant (preservative) mixture to extend the shelf life of Catalent's current vitamin A soft gel supplement sold to Nutrition International. Due to regulations, there is added level of complexity to the project requiring that no synthetic preservatives be used.The Marquardt Group at the University of Windsor intends to better understand the stability and degradation of the vitamin A soft gel supplement, including the effect of various antioxidants on the degradation. The knowledge gained through this will lead to novel formulations designed to improve the stability of the vitamin A system and thereby improving the lives of people.

Catalent是国际营养组织（前营养素倡议）最大的维生素A棕榈酸酯胶囊供应商之一，该组织旨在消除世界各地的营养不良。 目前，维生素A胶囊通过添加维生素E醋酸酯来稳定。然而，由于该产品通常分布在温度和湿度升高的恶劣气候中，与北美的储存相比，保质期缩短。如果能够开发出一种更稳定、保质期更长的脂质基系统，对患者和供应商都将是一个巨大的优势。该项目建议开发和实施一种新型抗氧化剂（防腐剂）混合物，以延长Catalent目前出售给Nutrition International的维生素A软凝胶补充剂的保质期。由于法规的规定，项目的复杂性增加了，要求不使用合成防腐剂。温莎大学的马夸特小组打算更好地了解维生素A软凝胶补充剂的稳定性和降解情况，包括各种抗氧化剂对降解的影响。由此获得的知识将导致新的配方，旨在提高维生素A系统的稳定性，从而改善人们的生活。