Development of natural antioxidant formulation for improved Vitamin A soft gelatin capsules stability and shelf-life

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Catalent is one of the largest suppliers of Vitamin A palmitate capsules to Nutrition International (previously Micronutrient Initiative), which is an organization aimed at eliminating malnutrition throughout the world. Currently, the Vitamin A capsules are stabilized by the addition of vitamin E acetate. However, as this product is often distributed in harsh climates with elevated temperatures and humidity, the shelf-life is reduced compared to storage in North America. It would be a great advantage to both patients and providers if a more stable lipid-based system with a longer shelf life could be developed. This project proposes to develop and implement a novel antioxidant (preservative) mixture to extend the shelf life of Catalent's current vitamin A soft gel supplement sold to Nutrition International. Due to regulations, there is added level of complexity to the project requiring that no synthetic preservatives be used.The Marquardt Group at the University of Windsor intends to better understand the stability and degradation of the vitamin A soft gel supplement, including the effect of various antioxidants on the degradation. The knowledge gained through this will lead to novel formulations designed to improve the stability of the vitamin A system and thereby improving the lives of people.