Physiological and cellular responses to environmental stressors during the early life history stages of fishes.
鱼类生命史早期阶段对环境压力的生理和细胞反应。
基本信息
- 批准号:RGPIN-2019-06128
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Temperature and low oxygen conditions (hypoxia) are perhaps the most common environmental stressors encountered by fish. Because they affect many aspects of biology they can substantially influence overall success and performance. In many instances, fish have evolved to cope with natural fluctuations in temperature and oxygen levels. However, global climate change and increased agriculture have resulted in rising water temperatures and eutrophication; these in turn have increased the frequency and magnitude of fluctuations in these stressors which pose a significant threat to fish populations. As a temperature sensitive, cold-water fish whose embryos develop in near freezing water, lake whitefish are an ideal species to study the effects of climate change and thermal pollution on fish. Moreover, lake whitefish are economically important and culturally significant to Canada's Indigenous peoples. This research program will increase our understanding of how environmental stressors affect fish in critical and sensitive early life stages from fertilization to the end of the first year of life. The goal is an understanding of how stressors interact and alter biology at the cellular, physiological and whole animal levels as fish cope, acclimatize and adapt to changing environments. The short-term goals of the research are: (1) Determine the extent to which exposure to stressors in the parental and embryonic stages alter temperature and hypoxia tolerance in embryos and fish in their first year of life with emphasis on the early critical stages; (2) Provide a better understanding of how environmental stress changes metabolism at the cellular (carbohydrates and lipids) and whole animal (oxygen uptake, transport and consumption) levels during early life stages. With this research we also aim to identify the short- and long-term impacts of this reprogramming and determine if they are beneficial or detrimental to overall performance; (3) Determine the roles of the cellular (heat shock and antioxidant) and physiological (i.e., cortisol via the hypothalamic-pituitary-interrenal pathway) stress responses in tolerating these stressors; (4) Characterize the development of the hypothalamic-pituitary-interrenal and -thyroid axes in lake whitefish and examine the effects that embryonic stressors might have on these axes which are important for normal embryo and post-hatch development. Over the course of this research program, my research team (5 graduate and 7 undergraduate students) and I will significantly enhance our understanding of how temperature and hypoxia stress interact and affect fish at multiple levels of biological organization. With a focus on thermally sensitive, cold-water fish populations from various lake types, data generated will help us better predict the short- and long-term impacts of climate change and agricultural activities on lake whitefish and the extent to which fish may cope, acclimatize and adapt to changing environments.
温度和低氧条件(缺氧)可能是鱼类遇到的最常见的环境压力。 因为它们影响生物学的许多方面,它们可以实质性地影响整体的成功和表现。 在许多情况下,鱼类已经进化到能够科普温度和氧气水平的自然波动。 然而,全球气候变化和农业增加导致水温上升和富营养化;这反过来又增加了这些压力因素波动的频率和幅度,对鱼类种群构成重大威胁。 白鲑是一种对温度敏感的冷水性鱼类,其胚胎在接近冰点的水中发育,是研究气候变化和热污染对鱼类影响的理想物种。 此外,白鲑对加拿大土著人民具有重要的经济和文化意义。 这项研究计划将增加我们对环境压力如何影响鱼类从受精到生命第一年结束的关键和敏感的早期生命阶段的理解。 目标是了解压力源如何在细胞,生理和整个动物水平上相互作用并改变生物学,因为鱼类科普,适应和适应不断变化的环境。 研究的短期目标是:(1)确定在父母和胚胎阶段暴露于应激物在多大程度上改变胚胎和鱼类在其生命的第一年中的温度和缺氧耐受性,重点是早期关键阶段;(2)更好地了解环境压力如何改变细胞代谢(碳水化合物和脂质)和整个动物(氧摄取、运输和消耗)水平。 通过这项研究,我们还旨在确定这种重编程的短期和长期影响,并确定它们对整体表现是有益的还是有害的;(3)确定细胞(热休克和抗氧化剂)和生理(即,皮质醇通过下丘脑-垂体-肾间途径)耐受这些应激源的应激反应;(4)表征白鲑下丘脑-垂体-肾间和甲状腺轴的发育,并检查胚胎应激源可能对这些轴的影响,这些轴对正常胚胎和孵化后发育很重要。 在这个研究项目的过程中,我和我的研究团队(5名研究生和7名本科生)将显着提高我们对温度和缺氧应激如何在多个生物组织水平上相互作用和影响鱼类的理解。 重点关注各种湖泊类型的热敏冷水鱼类种群,所产生的数据将帮助我们更好地预测气候变化和农业活动对白鲑的短期和长期影响,以及鱼类科普,适应和适应不断变化的环境的程度。
项目成果
期刊论文数量(0)
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{{ truncateString('Manzon, Richard', 18)}}的其他基金
Physiological and cellular responses to environmental stressors during the early life history stages of fishes.
鱼类生命史早期阶段对环境压力的生理和细胞反应。
- 批准号:
RGPIN-2019-06128 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Physiological and cellular responses to environmental stressors during the early life history stages of fishes.
鱼类生命史早期阶段对环境压力的生理和细胞反应。
- 批准号:
RGPIN-2019-06128 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Physiological and cellular responses to environmental stressors during the early life history stages of fishes.
鱼类生命史早期阶段对环境压力的生理和细胞反应。
- 批准号:
RGPIN-2019-06128 - 财政年份:2020
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Environmental, hormonal and cellular correlates of thermal biology and adaptation in fish.
鱼类热生物学和适应的环境、激素和细胞相关性。
- 批准号:
RGPIN-2014-03831 - 财政年份:2018
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Environmental, hormonal and cellular correlates of thermal biology and adaptation in fish.
鱼类热生物学和适应的环境、激素和细胞相关性。
- 批准号:
RGPIN-2014-03831 - 财政年份:2017
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Environmental, hormonal and cellular correlates of thermal biology and adaptation in fish.
鱼类热生物学和适应的环境、激素和细胞相关性。
- 批准号:
RGPIN-2014-03831 - 财政年份:2016
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Environmental, hormonal and cellular correlates of thermal biology and adaptation in fish.
鱼类热生物学和适应的环境、激素和细胞相关性。
- 批准号:
RGPIN-2014-03831 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Environmental, hormonal and cellular correlates of thermal biology and adaptation in fish.
鱼类热生物学和适应的环境、激素和细胞相关性。
- 批准号:
RGPIN-2014-03831 - 财政年份:2014
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Thyroid regulation of fish development: physiological, cellular and molecular responses with evolutionary considerations
鱼类发育的甲状腺调节:考虑进化因素的生理、细胞和分子反应
- 批准号:
261948-2007 - 财政年份:2009
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Thyroid regulation of fish development: physiological, cellular and molecular responses with evolutionary considerations
鱼类发育的甲状腺调节:考虑进化因素的生理、细胞和分子反应
- 批准号:
261948-2007 - 财政年份:2008
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
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Physiological and cellular responses to environmental stressors during the early life history stages of fishes.
鱼类生命史早期阶段对环境压力的生理和细胞反应。
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Physiological and cellular responses to environmental stressors during the early life history stages of fishes.
鱼类生命史早期阶段对环境压力的生理和细胞反应。
- 批准号:
RGPIN-2019-06128 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms of change, cellular responses of the fish heart to physiological stress
鱼心脏对生理应激的变化机制、细胞反应
- 批准号:
RGPIN-2017-06292 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Mechanisms of change, cellular responses of the fish heart to physiological stress
鱼心脏对生理应激的变化机制、细胞反应
- 批准号:
RGPIN-2017-06292 - 财政年份:2020
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual