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Investigating the therapeutic potential of modulating lysosomal biogenesis in normal and leukemic human hematopoietic stem cells

Investigating the therapeutic potential of modulating lysosomal biogenesis in normal and leukemic human hematopoietic stem cells
研究调节正常和白血病人类造血干细胞溶酶体生物发生的治疗潜力
批准号：
413212
负责人：
Garcia Prat Laura
金额：
$9.83万
依托单位：
University Health Network (Toronto)
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-10-01 至 2022-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=413212&lang=en
关键词：
Autophagy Chemotherapy Resistance Hematopoiesis Hematopoietic Stem Cell Transplant Hematopoietic Stem Cells Leukaemia Leukemia Stem Cells Lysosomal Biogenesis Patient-Derived Xenotransplants Transcription Factor Eb

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Currently, leukemia is treated by hematopoietic stem cell transplant (HSCT) and/or chemotherapies; however, there are challenges. Although 50,000 HSCT procedures are undertaken worldwide annually to treat blood disorders and cancers, two thirds of patient
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