Apple proanthocyanidins and their metabolites: mechanisms of action in biological systems

苹果原花青素及其代谢物:生物系统中的作用机制

基本信息

  • 批准号:
    RGPIN-2017-04594
  • 负责人:
  • 金额:
    $ 2.84万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2019
  • 资助国家:
    加拿大
  • 起止时间:
    2019-01-01 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

Canada faces significant challenges from population chronic and metabolic disease epidemics, which are directly or indirectly linked to the human diet. The regular consumption of diets rich in fruits and vegetables has been consistently associated with the promotion of beneficial physiological functions leading to human health and wellness. These health benefts have been attributed to biologically active, plantbased polyphenolic compounds, especially flavonoids, commonly found in fruits and vegetables. A large body of epidemilogical studies has strongly suggested that habitual dietary flavonoid intake can reduce the risk of numerous diseases including some cancers. *** A specific class of polymerized flavonoids, proanthocyanidins, represent over 50% of dietary polyphenols consumed; however, these polyphenols are poorly absorbed in the small intestine and therefore their beneficial effects are dependent on the colonic microflora of individuals. In the proposed research, polymeric proanthocyanidins isolated from apple processing waste will be bioconverted into simple bioactive molecules using isolated probiotic bacteria. The resulting newly formed molecules will be characterized by their structure, safety, and beneficial physiological functions. Understanding the molecular mechanisms of pleiotropic beneficial effects on human health such as antioxidant, anti-inflammatory, and anti-carcinogenic activities of probiotic metabolites of apple proanthocyanidins will be significant to advance the future approach to managing chronic disorders. Highly qualified personnel (HQP) will be trained in interdisciplinary emerging areas of nutritional metabolomics of bioactive compounds present in fruits. *** The overall goal of the research program is to elucidate the mechanisms of action of fruit flavonoids and their metabolites in relation to the specific physiological functions. The new knowledge generated through this research program will contribute to the development of flavonoid-based functional foods and nutraceuticals that will reduce the risk of chronic disorders of humans. The research findings will immensely advance the fundamental knowledge needed to develop effective cancer chemoprotective strategies. For example, apple proanthocyanidins can be developed as a unique prebiotic along with probiotic bacteria to introduce novel cancer preventive functional foods. The newly formed efficacious metabolites of proanthocyanidins can be used as candidates for anti-cancer drugs. As a result, underutilized apple processing waste can be turned into a valuable source of food ingredients and nutraceuticals, and in turn, these may contribute to reducing economic burdens associated with cancer incidence and mortality in our society.
加拿大面临着人口慢性病和代谢性疾病流行的重大挑战,这些疾病与人类饮食直接或间接相关。经常食用富含水果和蔬菜的饮食一直与促进有益的生理功能有关,从而促进人类健康和健康。 这些健康益处归因于生物活性的植物多酚化合物,特别是黄酮类化合物,通常存在于水果和蔬菜中。 大量的药理学研究强烈表明,习惯性膳食黄酮摄入可以降低许多疾病的风险,包括一些癌症。 *** 一类特殊的聚合类黄酮,原花色素,代表超过50%的膳食多酚消耗;然而,这些多酚在小肠中吸收不良,因此它们的有益效果取决于个体的结肠微生物区系。在拟议的研究中,从苹果加工废物中分离的聚合原花青素将使用分离的益生菌生物转化为简单的生物活性分子。由此产生的新形成的分子将通过其结构、安全性和有益的生理功能来表征。了解苹果原花青素的益生菌代谢产物对人类健康的多效性有益作用的分子机制,如抗氧化,抗炎和抗癌活性,将对推进未来管理慢性疾病的方法具有重要意义。高素质的人员(HQP)将在水果中存在的生物活性化合物的营养代谢组学的跨学科新兴领域进行培训。*** 研究计划的总体目标是阐明水果类黄酮及其代谢产物与特定生理功能相关的作用机制。通过这项研究计划产生的新知识将有助于开发基于类黄酮的功能性食品和营养保健品,从而降低人类慢性疾病的风险。研究结果将极大地推进开发有效的癌症化学保护策略所需的基础知识。 例如,苹果原花青素可以作为独特的益生元沿着益生菌开发,以引入新型癌症预防功能食品。新形成的原花青素有效代谢产物可作为抗癌药物的候选物。 因此,未充分利用的苹果加工废物可以变成食品成分和营养保健品的宝贵来源,反过来,这些可能有助于减少我们社会中与癌症发病率和死亡率相关的经济负担。

项目成果

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{{ truncateString('Rupasinghe, HPVasantha', 18)}}的其他基金

Apple proanthocyanidins and their metabolites: mechanisms of action in biological systems
苹果原花青素及其代谢物:生物系统中的作用机制
  • 批准号:
    RGPIN-2017-04594
  • 财政年份:
    2021
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Apple proanthocyanidins and their metabolites: mechanisms of action in biological systems
苹果原花青素及其代谢物:生物系统中的作用机制
  • 批准号:
    RGPIN-2017-04594
  • 财政年份:
    2020
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
A flow cytometer for investigating functions and mechanisms of plant-food flavonoids in biological systems
用于研究植物性食品类黄酮在生物系统中的功能和机制的流式细胞仪
  • 批准号:
    RTI-2019-00528
  • 财政年份:
    2018
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Research Tools and Instruments
Apple proanthocyanidins and their metabolites: mechanisms of action in biological systems
苹果原花青素及其代谢物:生物系统中的作用机制
  • 批准号:
    RGPIN-2017-04594
  • 财政年份:
    2018
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Apple proanthocyanidins and their metabolites: mechanisms of action in biological systems
苹果原花青素及其代谢物:生物系统中的作用机制
  • 批准号:
    RGPIN-2017-04594
  • 财政年份:
    2017
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Fruit flavonoids and their metabolites: mechanisms of action in biological systems
水果类黄酮及其代谢物:生物系统中的作用机制
  • 批准号:
    RGPIN-2016-05369
  • 财政年份:
    2016
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
Fruit Bioproducts
水果生物制品
  • 批准号:
    1000220744-2010
  • 财政年份:
    2016
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Canada Research Chairs
Fruit Bioproducts
水果生物制品
  • 批准号:
    1220744-2010
  • 财政年份:
    2015
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Canada Research Chairs
Fruit Bioproducts
水果生物制品
  • 批准号:
    1000220744-2010
  • 财政年份:
    2014
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Canada Research Chairs
Fruit Bioproducts
水果生物制品
  • 批准号:
    1000220744-2010
  • 财政年份:
    2013
  • 资助金额:
    $ 2.84万
  • 项目类别:
    Canada Research Chairs

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苹果原花青素及其代谢物:生物系统中的作用机制
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  • 资助金额:
    $ 2.84万
  • 项目类别:
    Discovery Grants Program - Individual
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Apple proanthocyanidins and their metabolites: mechanisms of action in biological systems
苹果原花青素及其代谢物:生物系统中的作用机制
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