Development of new Synthons, Catalysts and Applications in Organic Synthesis

新型合成剂、催化剂的开发及其在有机合成中的应用

• 批准号: RGPIN-2017-06495
• 负责人: McNulty, James
• 金额: $ 3.28万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632758
• 关键词: Development; new; Synthons; Catalysts; Applications

This program of research concerns the development of methods that utilize relatively inexpensive, available building block chemicals known as olefins and olefin derivatives, using catalytic techniques, such as transition metal catalysis and organocatalysis, and to convert these building blocks to high value chiral intermediates using asymmetric cycloaddition reactions. The products of these reactions are either directly useful as, or may be conveniently converted to, biologically active natural products and/or derivatives thereof.

该研究计划涉及开发利用相对便宜的，可用的结构单元化学品（称为烯烃和烯烃衍生物），使用催化技术（如过渡金属催化和有机催化），并使用不对称环加成反应将这些结构单元转化为高价值的手性中间体的方法。这些反应的产物可直接用作或可方便地转化为生物活性天然产物和/或其衍生物。