Modeling and Evaluating Pulmonary Ventilation/Perfusion Mismatch

本CRD的主要目的是开发一个数学模型，以评估肺气体通气和肺中的气-血灌注的不匹配。与Rostrum Medical Innovations Inc.合作（温哥华，加拿大），我们的工业合作伙伴，我们的目标是回答以下问题：（i）我们可以得出一个测量的肺内分流（缺乏通气）的肺使用可测量的吸入和呼出气体分数？(ii)我们能否识别死腔（无气-血灌注的区域）和/或肺通气不足引起的气体通气和气-血灌注不匹配的差异？(iii)在出现呼吸窘迫的情况下，如重度肺泡萎陷或肺水肿，在呼吸机和呼气末正压同时调节下，血气水平和组织损伤会发生什么变化？我们的长期目标是为Rostrum提供与数据分析和定量建模相关的关键工具和见解，这对他们的业务战略至关重要。由此产生的影响是一个更健康的加拿大，并对加拿大经济产生积极影响。

The main objective of this CRD is to develop a mathematical model to evaluate the mismatch of pulmonary gas ventilation and gas-blood perfusion in the lungs. Working with Rostrum Medical Innovations Inc. (Vancouver, Canada), our industrial partner, we aim to answer the following questions: (i) Can we derive a measurement of the intrapulmonary shunt (lack of ventilation) of a lung using measurable inhaled and exhaled gas fractions? (ii) Can we identify differences in gas ventilation and gas-blood perfusion mismatch induced by dead space (areas of no gas-blood perfusion) and/or lack of ventilation in the lung? (iii) In the presence of respiratory distress, such as severe alveoli collapse or pulmonary edema, what happens to blood gas levels and tissue damage under the simultaneous adjustment of the ventilator and positive end-expiratory pressure? Our long term goal is to provide Rostrum with key tools and insights related to data analytics and quantitative modelling that are central to their business strategy. The resulting impact is a healthier Canada and a positive impact on the Canadian economy.