New Tools and Methods for Organic Synthesis

化合物及其衍生物在日常生活中具有极其重要的意义。因此，多年来在化学研究领域进行了大量和持续的投资，以产生新的知识和开发新的应用，这并不奇怪。值得注意的是，有机化学领域的研究人员在这一总体过程中发挥了重要作用。虽然合成化学家目前有多种方法来生产有机化合物，但仍然需要新的合成工具，使反应以更高的效率和选择性进行，并需要新的工艺，使其能够获得原始结构基序或解决当前的可持续性和环境影响问题。***目前的研究计划围绕三个主要主题：均相金催化，氢转移反应和碳化学，这是有机化学中最活跃的领域，都为解决上述问题提供了机会。近年来，均相金催化受到了科学界的广泛关注。金配合物在其他官能团存在的情况下选择性结合碳pi系统的能力为发现新的选择性转化提供了独特的机会。我们在这一领域的研究将集中在设计和合成新的金催化剂，以及开发高效和选择性的金催化转化来合成有价值的结构基序。亲电活化或自由基条件下的氢转移是有机分子功能化和快速增加其结构复杂性的有效方法。在这一领域，我们将通过C-H键的功能化来开发制药工业感兴趣的杂环分子的新途径，并研究烯烃的氢功能化以合成重要的手性结构基序。最后，通过利用碳化合物的特殊反应性及其在有机化学中的广泛适用性，我们将致力于非常规碳化合物前体的开发和化学研究。***总体而言，这一多元化研究项目的成果有望通过提供设计有机分子结构的新方法，直接影响化学合成领域。

Chemical compounds and their derivatives are of tremendous importance in everyday life. It is therefore not surprising that substantial and continuous investments have been made in the chemistry research field over the years to generate new knowledge and develop new applications. It is worth noting that researchers in the field of organic chemistry play an important role in this general process. Although synthetic chemists currently have access to a variety of methods to produce organic compounds, there still exists a need for new synthetic tools allowing reactions to proceed with better efficiency and selectivity, and for new processes allowing access to original structural motifs or addressing the current questions of sustainability and environmental impact.***The present research program is structured around three main themes: homogeneous gold catalysis, hydrogen transfer reactions and carbene chemistry, which are among the most active areas in organic chemistry and all offer opportunities to address the above-mentioned issues. In the recent years, homogenous gold catalysis has received considerable attention by the scientific community. The ability of gold complexes to selectively bind to carbon pi-systems in the presence of other functional groups provides a unique opportunity for the discovery of novel selective transformations. Our research in this field will focus on the design and synthesis of new gold catalysts, and on the development of efficient and selective gold-catalyzed transformations for the synthesis of valuable structural motifs. Transfer of hydrogen under electrophilic activation or under radical conditions represents a useful method to functionalize organic molecules and rapidly increase their structural complexity. In this domain, we will develop new access to heterocyclic molecules of interest to the pharmaceutical industry by functionalization of C-H bonds and study the hydrofunctionalization of alkenes for the synthesis of important chiral structural motifs. Finally, by capitalizing on the exceptional reactivity of carbenic species and on their broad applicability in organic chemistry, we will work on the development of unconventional carbene precursors and study their chemistry.***Overall, the outcomes of this diversified research program are expected to directly impact the field of chemical synthesis by providing new ways to design the construction of organic molecules.