An integrated spectroscopy-ultrasound surgical navigation system for residual cancer detection in breast surgery.

每8名妇女中就有1人罹患乳腺癌，是女性癌症相关死亡的第二大原因。理想的治疗方法是在早期进行乳房保护手术，在保留健康组织的同时切除癌症。不幸的是，目前的切除方法具有高达近40%的高阳性边缘率（当切除标本的边缘发现癌细胞时）。阳性切缘与高复发概率有关，因此需要重复手术。平均每3名接受保乳手术的女性中，就有1名因边缘呈阳性而需要至少再做一次手术。重复手术会导致术后并发症、化妆品受损、放射治疗延迟、心理困扰增加以及二次全身麻醉的成本和风险增加。重复手术往往导致全乳切除术，这是一个创伤的经验，病人谁期望治愈治疗乳房保留。通过开发一种独特的手术导航系统，将术中超声成像与声学光谱技术相结合，我们打算在将患者从手术台上释放之前确保切除腔内没有肿瘤。我们利用传统的超声波扫描仪，同时建立一个独特的光谱超声探头，因此产生的系统将是负担得起的，加拿大所有的护理机构都可以使用。拟议的系统应能够显著降低阳性边际率，从而减少重复手术的次数，并显著提高患者的生活质量，显著降低医疗保健费用。

Breast cancer affects 1 in 8 women during their lives and is the second-leading cause of female cancer related deaths. The ideal treatment is breast-conservation surgery , during its early stage, to remove cancer while conserving healthy tissue.Unfortunately, the current resection methods have high positive margin rates (when cancer cells are found on the edge of the resected specimen) of up to nearly 40%. Positive margins are linked to high probability of recurrence and thus require repeatsurgery. On average, one out of every three women undergoing breast-conservation surgery needs at least one additional surgery due to positive margins. Repeat surgery leads to increased risk of postoperative complications, impaired cosmetics, delayed radiation therapy, increased psychological distress, and increased costs and risks of asecond general anesthesia. Repeat surgery often leads to full mastectomy, which is a traumatic experience for a patient who expected a curative treatment with breastconservation. Through development of a unique surgical navigation system thatintegrates intra-operative ultrasound imaging with an acoustic spectroscopy technique, we intend to ensure that the resection cavity is clear of cancer before releasing the patient from the operating table. We take advantage of conventional ultrasoundscanners, while building a unique spectroscopic-ultrasound probe, and thus the resulting system will be affordable and accessible to all care facilities in Canada. The proposed system should enable significant reduction in positive margin rates, thereby reducing the number of repeat surgeries, and yielding significant quality of life benefits to patients and a significant reduction in health care costs.