Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
基本信息
- 批准号:RGPIN-2016-04790
- 负责人:
- 金额:$ 5.46万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2019
- 资助国家:加拿大
- 起止时间:2019-01-01 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Our laboratory is interested in the development of novel separation and detection methods for chemical analysis. Chemical analysis forms the basis for discovery in a wide variety of disciplines (e.g. environmental, medical and “omics” related research areas). The development of analysis systems that are faster, require less sample with increased sensitivity are in constant demand and become critical to probing e.g. biological and chemical systems in a variety of matrices. Our laboratory will develop droplet-based (digital) microfluidic platforms that combine low friction surfaces (superhydrophobic and super amphiphobic) with both magnetic and gravity-based droplet actuation and apply them to rapid/sensitive chemical analysis. My program will involve the synthesis and characterization of novel inorganic and polymer-based materials for low friction surface coatings and probe novel microfabrication methodologies to enable facile device fabrication (e.g. laser micromachining). Superhydrophobic/amphiphobic surfaces are characterized by extremely high contact angles (150 o) when droplets, of for example water, are placed upon their surface. The superhydrophobicity/amphiphobicity is generated through a combination of both surface chemistry and surface topography. The minimal surface adhesion enables the manipulation of droplets through the application of small forces (< 1 µN) on the droplet. A droplet can be rapidly actuated by introducing superparamagnetic particles to an aqueous droplet on a low friction surface, and applying a magnetic field (with speeds in excess of 50 cm/sec!). Alternatively we have shown that droplets can be manipulated using dissolved paramagnetic salts even though their magnetic susceptibility is approximately 10,000X less than that of the superparamagnetic particles. Paramagnetic particles can be functionalized with proteins, stationary phases, or with antibodies to conduct chemistry within the individual droplets. In this way multiplexed sample preparation prior to chemical analysis can be conducted (e.g. solid phase extraction, immuno-capture or derivatization). We will leverage my research group's and our collaborator's experience in mass spectrometry (MALDI and DESI-MS), fluorescence, electrochemical and absorbance detection to analyze of a variety of analytes (e.g. biomarkers, biosynthetic enzymes, environmental contaminants, etc.) within droplets following sample preparation. Our laboratory collaborates with a number of academic and industrial partners (e.g. NSERC Engage, Strategic and CREATE programs) to further augment and internationalize the training of researchers involved within my research program. The combination of experiences in microfabrication, microfluidics, mass spectrometry and surface science will provide students with a skill set relevant to the industrial, governmental and academic sectors.
我们实验室对开发用于化学分析的新型分离和检测方法很感兴趣。化学分析是众多学科(如环境、医学和“组学”相关研究领域)发现的基础。分析系统的发展速度更快,需要更少的样品和更高的灵敏度是不断需求的,并且成为探测各种基质中的生物和化学系统的关键。我们的实验室将开发基于液滴的(数字)微流控平台,将低摩擦表面(超疏水和超疏水)与基于磁和重力的液滴驱动结合起来,并将其应用于快速/敏感的化学分析。我的项目将包括用于低摩擦表面涂层的新型无机和聚合物基材料的合成和表征,以及探索新型微加工方法,以实现易于制造的设备(例如激光微加工)。超疏水/双疏水表面的特征是当水滴(例如水)放置在其表面时具有极高的接触角(150°)。超疏水/两疏性是表面化学和表面形貌共同作用的结果。最小的表面附着力可以通过在液滴上施加很小的力(< 1 μ N)来操纵液滴。通过将超顺磁粒子引入低摩擦表面的液滴,并施加磁场(速度超过50厘米/秒!),可以快速驱动液滴。另外,我们已经证明,液滴可以使用溶解的顺磁盐来操纵,即使它们的磁化率比超顺磁粒子的磁化率低约10,000倍。顺磁粒子可以与蛋白质、固定相或抗体功能化,在单个液滴内进行化学反应。通过这种方法,可以在化学分析之前进行多路样品制备(例如,固相萃取、免疫捕获或衍生化)。我们将利用我的研究小组和我们的合作者在质谱(MALDI和DESI-MS),荧光,电化学和吸光度检测方面的经验来分析样品制备后液滴内的各种分析物(例如生物标志物,生物合成酶,环境污染物等)。我们的实验室与许多学术和工业合作伙伴(例如NSERC Engage, Strategic和CREATE计划)合作,进一步扩大和国际化研究人员参与我的研究计划的培训。结合微加工、微流体、质谱和表面科学方面的经验,将为学生提供与工业、政府和学术部门相关的技能。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Oleschuk, Richard其他文献
Organic-free, versatile sessile droplet microfluidic device for chemical separation using an aqueous two-phase system
- DOI:
10.1039/c8lc01121d - 发表时间:
2019-02-21 - 期刊:
- 影响因子:6.1
- 作者:
Hermann, Matthias;Agrawal, Prashant;Oleschuk, Richard - 通讯作者:
Oleschuk, Richard
Hydrophobic/hydrophilic patterned surfaces for directed evaporative preconcentration
- DOI:
10.1039/c9an01782h - 发表时间:
2020-01-21 - 期刊:
- 影响因子:4.2
- 作者:
Tucker, Ben;Hermann, Matthias;Oleschuk, Richard - 通讯作者:
Oleschuk, Richard
Photoinduced polymerization for entrapping of octadecylsilane microsphere columns for capillary electrochromatography
- DOI:
10.1021/ac061349t - 发表时间:
2007-02-15 - 期刊:
- 影响因子:7.4
- 作者:
Xie, Ruixi;Oleschuk, Richard - 通讯作者:
Oleschuk, Richard
Detection of Opioids on Mail/Packages Using Open Port Interface Mass Spectrometry (OPI-MS)
- DOI:
10.1021/jasms.0c00295 - 发表时间:
2020-11-04 - 期刊:
- 影响因子:3.2
- 作者:
Metwally, Haidy;Agrawal, Prashant;Oleschuk, Richard - 通讯作者:
Oleschuk, Richard
Oleschuk, Richard的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Oleschuk, Richard', 18)}}的其他基金
Democratization of Mass Spectrometry Through Simplified Sample Preparation/Ionization for High Impact Applications
通过简化样品制备/电离实现高影响应用的质谱分析大众化
- 批准号:
RGPIN-2022-03833 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2021
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2020
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
Advanced sample introduction methods for mass spectrometry
用于质谱分析的先进进样方法
- 批准号:
521373-2018 - 财政年份:2020
- 资助金额:
$ 5.46万 - 项目类别:
Strategic Projects - Group
Advanced sample introduction methods for mass spectrometry
用于质谱分析的先进进样方法
- 批准号:
521373-2018 - 财政年份:2019
- 资助金额:
$ 5.46万 - 项目类别:
Strategic Projects - Group
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2018
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
Advanced sample introduction methods for mass spectrometry******
用于质谱分析的先进进样方法*****
- 批准号:
521373-2018 - 财政年份:2018
- 资助金额:
$ 5.46万 - 项目类别:
Strategic Projects - Group
Regional industry networking event with Queen's micro and nano focused researchers
与女王大学微米和纳米研究人员共同举办的区域行业网络活动
- 批准号:
508933-2017 - 财政年份:2017
- 资助金额:
$ 5.46万 - 项目类别:
Connect Grants Level 2
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2017
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2016
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
Data-driven Recommendation System Construction of an Online Medical Platform Based on the Fusion of Information
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国青年学者研究基金项目
Incentive and governance schenism study of corporate green washing behavior in China: Based on an integiated view of econfiguration of environmental authority and decoupling logic
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
Exploring the Intrinsic Mechanisms of CEO Turnover and Market Reaction: An Explanation Based on Information Asymmetry
- 批准号:W2433169
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
A study on prototype flexible multifunctional graphene foam-based sensing grid (柔性多功能石墨烯泡沫传感网格原型研究)
- 批准号:
- 批准年份:2020
- 资助金额:20 万元
- 项目类别:
基于tag-based单细胞转录组测序解析造血干细胞发育的可变剪接
- 批准号:81900115
- 批准年份:2019
- 资助金额:21.0 万元
- 项目类别:青年科学基金项目
应用Agent-Based-Model研究围术期单剂量地塞米松对手术切口愈合的影响及机制
- 批准号:81771933
- 批准年份:2017
- 资助金额:50.0 万元
- 项目类别:面上项目
Reality-based Interaction用户界面模型和评估方法研究
- 批准号:61170182
- 批准年份:2011
- 资助金额:57.0 万元
- 项目类别:面上项目
Multistage,haplotype and functional tests-based FCAR 基因和IgA肾病相关关系研究
- 批准号:30771013
- 批准年份:2007
- 资助金额:30.0 万元
- 项目类别:面上项目
差异蛋白质组技术结合Array-based CGH 寻找骨肉瘤分子标志物
- 批准号:30470665
- 批准年份:2004
- 资助金额:8.0 万元
- 项目类别:面上项目
GaN-based稀磁半导体材料与自旋电子共振隧穿器件的研究
- 批准号:60376005
- 批准年份:2003
- 资助金额:20.0 万元
- 项目类别:面上项目
相似海外基金
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of mRNA, Lipid Nanoparticle Based HIV Immunogens
基于 mRNA、脂质纳米颗粒的 HIV 免疫原的 cGMP 制造、灌装、释放、分析和稳定性测试以及稳定性计划
- 批准号:
10927030 - 财政年份:2023
- 资助金额:
$ 5.46万 - 项目类别:
Microfluidics-based solid cancer models as T-cell killing assays to transform healthcare manufacturing and analytical technologies
基于微流体的实体癌症模型作为 T 细胞杀伤分析,以改变医疗保健制造和分析技术
- 批准号:
2868602 - 财政年份:2023
- 资助金额:
$ 5.46万 - 项目类别:
Studentship
Paper-based high shear hemostatic analytical device
纸基高剪切止血分析装置
- 批准号:
10649056 - 财政年份:2023
- 资助金额:
$ 5.46万 - 项目类别:
Combining numerical and analytical approaches for precision cosmology based on galaxy statistics
基于星系统计的精密宇宙学结合数值和分析方法
- 批准号:
22K03634 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Developing an integrated analytical platform for evaluating the role of forest biorefineries in achieving a sustainable circular bio-based economy
开发综合分析平台,用于评估森林生物精炼厂在实现可持续循环生物经济中的作用
- 批准号:
576235-2022 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Vanier Canada Graduate Scholarship Tri-Council - Doctoral 3 years
Development of an analytical model for PET-based range verification in heavy ion therapy
开发重离子治疗中基于 PET 范围验证的分析模型
- 批准号:
22K20873 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Development of analytical and bioinformatic tools for mass spectrometry-based untargeted metabolomics
开发基于质谱的非靶向代谢组学分析和生物信息学工具
- 批准号:
RGPIN-2020-04895 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
NeurAssist- An innovative AI-based neuro-imaging platform that assists clinicians with unbiased AI predictions and analytical tools.
NeurAssist - 一个基于人工智能的创新神经影像平台,通过公正的人工智能预测和分析工具帮助临床医生。
- 批准号:
10043592 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Grant for R&D
Unit operations for fully automated microfluidic paper-based analytical devices for diagnostic and biosensing
用于诊断和生物传感的全自动微流体纸基分析设备的单元操作
- 批准号:
RGPIN-2019-05528 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别:
Discovery Grants Program - Individual
Development of a cloud-based analytical tool for polygenic risk score and its implication in heart failure research.
开发基于云的多基因风险评分分析工具及其对心力衰竭研究的影响。
- 批准号:
10826562 - 财政年份:2022
- 资助金额:
$ 5.46万 - 项目类别: