Advanced sample introduction methods for mass spectrometry

质谱仪具有无与伦比的性能，用于在极低浓度的复杂样品中鉴定化学和生化物种。该方案描述了由工业合作伙伴SCIEX商业化的革命性质谱学采样接口与拉瓦尔大学的光纤制造技术以及女王大学开发的先进涂层和机械加工技术的结合。Queen‘s和Laval在基于材料的研究及其用于化学传感方面有着良好的记录，而SCIEX在将加拿大大学的知识产权推向市场用于质谱学应用方面拥有40年的历史。超疏水和仿生材料通过化学组成和微纳米结构的结合，获得了新颖的爱水/怕水和吸附特性。这项提议将开发先进的制造方法来制备这些材料，以帮助进行质谱学样品制备，例如，可以创建大量样品(例如唾液、尿液、血液、脊髓液)，并将其存储为亚微升(&lt；0.00000001 L)液滴或干燥斑点。几千个水滴可以在短短几秒钟内“排列好”。快速样品制备非常适合新型质谱学接口(开放端口探头)，这是一项获得SCIEX授权的大学技术，能够以每秒5个样品的速度注入和分析液滴！该项目利用了女王大学和拉瓦尔大学和政府(联邦和省级)3000万美元的投资。尽管该项目的具体目标是结合和发展MS样品制备和成像，但这三家机构认为，这是SCIEX、Laval和皇后大学在质谱学技术开发方面更广泛合作的开始。HQP将通过在SCIEX和两个学术机构接受关于最先进的制造设备和分析仪器的培训而受益匪浅。培训将把学生定位为未来的领导者和创新者，这将继续推动加拿大在先进制造和分析测量方面走在前列。

Mass spectrometers possess unparalleled performance for the identification of chemical and biochemical species, in complex samples, at extremely low concentrations. This proposal describes the combination of a revolutionary mass spectrometric sampling interface commercialized by the industrial partner SCIEX, with fiber fabrication techniques at Université Laval and advanced coatings and machining techniques developed at Queen's University. Queen's and Laval have a strong record of materials-based research and its use for chemical sensing, and SCIEX a 40 year history of bringing Canadian University intellectual property to market for mass spectrometry applications. Superhydrophobic and biomimetic materials obtain their novel water loving/fearing, and sorptive characteristics through a combination of both chemical make-up and micro-nano structure. This proposal will develop advanced manufacturing methods to prepare these materials to aid in mass spectrometric sample preparation where for example large arrays of samples (e.g. fluids such as saliva, urine, blood, spinal fluid) can be created and stored as sub-microliter (<0.00000001 L) droplets or dried spots. Thousands of droplets can be "arrayed" in only a matter of seconds. The rapid sample preparation is well suited to the novel mass spectrometric interface (open port probe), a university technology licensed by SCIEX that is able to inject and analyze droplets at speeds as fast as 5 samples per second! The project leverages > $30 million in University and Governmental (Federal and Provincial) investment at Queen's University and Laval. Although this project has a specific aim to combine and develop MS sample preparation and imaging, the organizations believe this is the beginning of larger relationship between SCIEX, Laval and Queen's University concerning mass spectrometric technology development. HQP will benefit considerably through training at SCIEX, and both academic institutions on state-of-the-art manufacturing equipment and analytical instrumentation. The training will position the students as future leaders and innovators which will continue to propel Canada to the forefront of advanced manufacturing and analytical measurement.