Advanced sample introduction methods for mass spectrometry

质谱仪具有无与伦比的性能鉴定化学和生物化学物种，在复杂的样品，在极低的浓度。该提案将工业合作伙伴SCIEX商业化的革命性质谱采样接口与拉瓦尔大学的纤维制造技术和皇后大学开发的先进涂层和加工技术相结合。Queen's和Laval在基于材料的研究及其在化学传感中的应用方面有着强大的记录，而SCIEX在将加拿大大学的知识产权推向质谱应用市场方面有着40年的历史。超疏水和仿生材料通过化学组成和微纳米结构的结合获得了新的亲水/憎水和吸附特性。该提案将开发先进的制造方法来制备这些材料，以帮助质谱样品制备，例如可以创建大阵列样品（例如唾液，尿液，血液，脊髓液等液体）并以亚微升（<0.00000001 L）液滴或干燥点的形式存储。数千个液滴可以在几秒钟内“排列”起来。快速样品制备非常适合新型质谱界面（开放端口探针），这是SCIEX授权的一项大学技术，能够以每秒5个样品的速度注入和分析液滴！该项目利用女王大学和拉瓦尔大学的大学和政府（联邦和省）投资3000万美元。虽然这个项目的具体目标是结合和发展质谱样品制备和成像，但组织认为这是SCIEX， Laval和皇后大学在质谱技术发展方面更大关系的开始。HQP将通过SCIEX和两家学术机构在最先进的制造设备和分析仪器方面的培训受益匪浅。培训将把学生定位为未来的领导者和创新者，这将继续推动加拿大走在先进制造和分析测量的前沿。

Mass spectrometers possess unparalleled performance for the identification of chemical and biochemical species, in complex samples, at extremely low concentrations. This proposal describes the combination of a revolutionary mass spectrometric sampling interface commercialized by the industrial partner SCIEX, with fiber fabrication techniques at Université Laval and advanced coatings and machining techniques developed at Queen's University. Queen's and Laval have a strong record of materials-based research and its use for chemical sensing, and SCIEX a 40 year history of bringing Canadian University intellectual property to market for mass spectrometry applications. Superhydrophobic and biomimetic materials obtain their novel water loving/fearing, and sorptive characteristics through a combination of both chemical make-up and micro-nano structure. This proposal will develop advanced manufacturing methods to prepare these materials to aid in mass spectrometric sample preparation where for example large arrays of samples (e.g. fluids such as saliva, urine, blood, spinal fluid) can be created and stored as sub-microliter (<0.00000001 L) droplets or dried spots. Thousands of droplets can be "arrayed" in only a matter of seconds. The rapid sample preparation is well suited to the novel mass spectrometric interface (open port probe), a university technology licensed by SCIEX that is able to inject and analyze droplets at speeds as fast as 5 samples per second! The project leverages > $30 million in University and Governmental (Federal and Provincial) investment at Queen's University and Laval. Although this project has a specific aim to combine and develop MS sample preparation and imaging, the organizations believe this is the beginning of larger relationship between SCIEX, Laval and Queen's University concerning mass spectrometric technology development. HQP will benefit considerably through training at SCIEX, and both academic institutions on state-of-the-art manufacturing equipment and analytical instrumentation. The training will position the students as future leaders and innovators which will continue to propel Canada to the forefront of advanced manufacturing and analytical measurement.