Canada Research Chair in Male Reproductive Toxicology

加拿大男性生殖毒理学研究主席

• 批准号: CRC-2017-00067
• 负责人: Cyr, Daniel
• 金额: $ 14.57万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694243
• 关键词: Canada; Research; Chair; Male; Reproductive

Environmental pollutants can exert a negative impact on wildlife reproduction. Male reproductive function appears to be particularly sensitive to pollutants, and in particular those that act as endocrine disruptor. Cellular barriers of the testis and epididymis create a specific environment in the lumen of these organs to enable spermatozoa to be formed, acquire motility and the ability to fertilize. This research Chair in Male Reproductive Toxicology will examine how the epididymis can maintain its barrier following chemical insult and the process by which the epithelium of this tissue can regenerate following chemical-induced cellular damage.

环境污染物会对野生动物的繁殖产生负面影响。男性生殖功能似乎对污染物特别敏感，特别是那些内分泌干扰物。 睾丸和附睾的细胞屏障在这些器官的内腔中创造了一个特定的环境，使精子能够形成，获得运动能力和受精能力。男性生殖毒理学的这一研究主席将研究附睾如何在化学损伤后保持其屏障，以及该组织的上皮在化学诱导的细胞损伤后再生的过程。