Assessing the toxicity and inflammatory response associated with human health and exposure to nanoplastics

评估与人类健康和接触纳米塑料相关的毒性和炎症反应

• 批准号: 558452-2020
• 负责人: Cyr, Daniel
• 金额: $ 18.21万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=721725
• 关键词: Assessing; toxicity; inflammatory; response; associated

The impacts of environmental contaminants on human health is a subject of ongoing concern. The emergence of plastics as global pollutants has received considerable attention. The degradation of plastic waste into smaller micro- and nanoplastic molecules, as well as their synthesis by various industries, has led to widespread distribution of these particles and their accumulation in aquatic wildlife species. The presence of these nano-sized particles in food, drinking water and in the atmosphere indicates that human exposure is inevitable, yet few studies have examined the effects of nanoplastics on human health. While the mechanisms by which environmental factors impact human health vary, dysregulated inflammation represents a common mechanism associated with multiple environmental factors. Such effects can result in, or exacerbate, pathological conditions leading to immune dysfunction, neurodegenerative diseases, and infertility. To address the effects of nanoplastics on inflammation and human health, we will assess the effects of nanoplastics on these different physiological systems in order to provide both comprehensive and essential information required to predict the risk of nanoplastics to human health. The proposed multidisciplinary approach will serve to generate Adverse Outcome Pathways that will enable the prediction of hazards for risk assessment, to identify data/testing gaps, and to formulate hypotheses regarding the modes of action of nanoplastics.

环境污染物对人类健康的影响是一个持续关注的问题。塑料作为全球污染物的出现受到了相当大的关注。塑料废物降解为更小的微米和纳米塑料分子，以及各种工业对其进行合成，导致这些颗粒广泛分布并在水生野生动物物种中积累。这些纳米颗粒在食物、饮用水和大气中的存在表明，人类接触这些颗粒是不可避免的，但很少有研究探讨纳米塑料对人类健康的影响。虽然环境因素影响人类健康的机制各不相同，但炎症失调是与多种环境因素相关的常见机制。这些影响可能导致或加剧导致免疫功能障碍、神经退行性疾病和不育的病理状况。为了解决纳米塑料对炎症和人类健康的影响，我们将评估纳米塑料对这些不同生理系统的影响，以提供预测纳米塑料对人类健康风险所需的全面和必要的信息。拟议的多学科方法将有助于产生不良后果途径，从而能够预测风险评估的危害，确定数据/测试差距，并制定有关纳米塑料作用模式的假设。