Assessing the toxicity and inflammatory response associated with human health and exposure to nanoplastics

环境污染物对人类健康的影响是一个持续关注的主题。塑料作为全球污染物的出现受到了相当大的关注。塑料废物被降解成更小的微塑料和纳米塑料分子，以及各种工业对其进行合成，导致这些颗粒在水生野生动物物种中广泛分布和积累。这些纳米颗粒在食物、饮用水和大气中的存在表明，人类不可避免地接触到纳米塑料，但很少有研究研究纳米塑料对人类健康的影响。虽然环境因素影响人类健康的机制各不相同，但失调的炎症反应是与多种环境因素相关的常见机制。这种影响可能导致或加剧导致免疫功能障碍、神经退行性疾病和不孕不育的病理状况。为了解决纳米塑料对炎症和人类健康的影响，我们将评估纳米塑料对这些不同生理系统的影响，以提供预测纳米塑料对人类健康风险所需的全面和必要的信息。拟议的多学科方法将有助于产生不利的结果路径，从而能够预测危险以进行风险评估，找出数据/测试差距，并就纳米塑料的作用模式提出假设。

The impacts of environmental contaminants on human health is a subject of ongoing concern. The emergence of plastics as global pollutants has received considerable attention. The degradation of plastic waste into smaller micro- and nanoplastic molecules, as well as their synthesis by various industries, has led to widespread distribution of these particles and their accumulation in aquatic wildlife species. The presence of these nano-sized particles in food, drinking water and in the atmosphere indicates that human exposure is inevitable, yet few studies have examined the effects of nanoplastics on human health. While the mechanisms by which environmental factors impact human health vary, dysregulated inflammation represents a common mechanism associated with multiple environmental factors. Such effects can result in, or exacerbate, pathological conditions leading to immune dysfunction, neurodegenerative diseases, and infertility. To address the effects of nanoplastics on inflammation and human health, we will assess the effects of nanoplastics on these different physiological systems in order to provide both comprehensive and essential information required to predict the risk of nanoplastics to human health. The proposed multidisciplinary approach will serve to generate Adverse Outcome Pathways that will enable the prediction of hazards for risk assessment, to identify data/testing gaps, and to formulate hypotheses regarding the modes of action of nanoplastics.