Assessing the toxicity and inflammatory response associated with human health and exposure to nanoplastics

环境污染物对人类健康的影响是一个持续关注的问题。塑料作为全球性污染物的出现已经引起了相当大的关注。塑料废物降解成更小的微和纳米塑料分子，以及各种工业的合成，导致这些颗粒广泛分布并在水生野生动物物种中积累。食物、饮用水和大气中这些纳米级颗粒的存在表明人类接触是不可避免的，但很少有研究审查纳米塑料对人类健康的影响。虽然环境因素影响人类健康的机制各不相同，但炎症失调代表了与多种环境因素相关的共同机制。这种影响会导致或加剧导致免疫功能障碍、神经退行性疾病和不孕症的病理状况。为了解决纳米塑料对炎症和人类健康的影响，我们将评估纳米塑料对这些不同生理系统的影响，以便为预测纳米塑料对人类健康的风险提供全面和必要的信息。拟议的多学科方法将有助于产生不利结果路径，从而能够预测风险评估的危害，识别数据/测试空白，并制定关于纳米塑料作用模式的假设。

The impacts of environmental contaminants on human health is a subject of ongoing concern. The emergence of plastics as global pollutants has received considerable attention. The degradation of plastic waste into smaller micro- and nanoplastic molecules, as well as their synthesis by various industries, has led to widespread distribution of these particles and their accumulation in aquatic wildlife species. The presence of these nano-sized particles in food, drinking water and in the atmosphere indicates that human exposure is inevitable, yet few studies have examined the effects of nanoplastics on human health. While the mechanisms by which environmental factors impact human health vary, dysregulated inflammation represents a common mechanism associated with multiple environmental factors. Such effects can result in, or exacerbate, pathological conditions leading to immune dysfunction, neurodegenerative diseases, and infertility. To address the effects of nanoplastics on inflammation and human health, we will assess the effects of nanoplastics on these different physiological systems in order to provide both comprehensive and essential information required to predict the risk of nanoplastics to human health. The proposed multidisciplinary approach will serve to generate Adverse Outcome Pathways that will enable the prediction of hazards for risk assessment, to identify data/testing gaps, and to formulate hypotheses regarding the modes of action of nanoplastics.