RNA Bioinformatics and Genomics

RNA生物信息学和基因组学

• 批准号: CRC-2016-00269
• 负责人: Zovoilis, Athanasios
• 金额: $ 8.74万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=696037
• 关键词: RNA; Bioinformatics; Genomics

This research program aims to identify novel non-coding RNAs in human based on the convergence of RNA bioinformatics, human genetics and biochemistry. It will focus on four classes of non-coding RNAs that have not been studied extensively until now, including repetitive, chimeric and circular RNAs. RNA sequencing and analysis pipelines will be optimized to allow detection of these RNAs while their structure and interaction with proteins will be tested in vitro. This research will contribute to a better understanding of the architecture and the variability of the non-coding transcriptome in human and the role of these RNAs in cellular function.

该研究计划旨在基于RNA生物信息学，人类遗传学和生物化学的融合来鉴定人类中的新型非编码RNA。它将集中在四类尚未被广泛研究的非编码RNA，包括重复，嵌合和环状RNA。RNA测序和分析管道将进行优化，以允许检测这些RNA，同时将在体外测试它们的结构和与蛋白质的相互作用。这项研究将有助于更好地了解人类非编码转录组的结构和变异性以及这些RNA在细胞功能中的作用。