Nuclear magnetic resonance methods for environmental diagnostics

拟议研究的目标是开发基于核磁共振（NMR）的先进分析方法，以改善复杂环境混合物的特性，包括：（i）开发新的分析方法，以快速识别和量化受污染地下水和复杂非水相液体（NAPL）中存在的有机成分;（二）确定对生物反应器消化池的最佳运作至关重要的关键化学参数变化的新工具;（三）探索用于受污染地下水生物补救的微生物群落的代谢组学特征。一般来说，环境样品的化学表征的传统方法是基于已知化学参数的目标分析。NMR可以说是研究化学和物理复杂系统的最强大的分析工具，然而，NMR在提高我们对环境问题的理解方面的应用相对于其在其他科学学科中的应用还不发达。拟议的研究将有助于NMR在环境科学的许多学科中的环境应用的不断发展，包括环境化学，环境微生物学和环境毒理学。拟议的研究计划将提供学术，经济，环境和社会效益，加拿大通过提供所需的新工具和知识，以加强和改善我们的环境实践，以确保继续获得健康的生态系统和清洁的水现在和未来。改进分析方法以确定受污染环境的特征，将有助于设计改进模型，以预测环境中污染物的分子归宿、行为和潜在危害。这些方法将有助于设计和实施战略和技术，以监测、减轻和补救敏感的环境系统。

The objective of the proposed research is to develop advanced analytical methods based on Nuclear Magnetic Resonance (NMR) to improve the characterization of complex environmental mixtures, including: (i) the development of novel analytical methods to rapidly identify and quantify the organic constituents present in contaminated groundwater and complex non-aqueous phase liquids (NAPL); (ii) new tools to identify variations in key chemical parameters important to the optimal operation of bioreactor digesters; and (iii) the exploration of metabolomics-based profiling of microbial communities used for the bioremediation of contaminated groundwater. In general, conventional approaches for the chemical characterization of environmental samples are based on the targeted analyses of known chemical parameters. NMR is arguably the most powerful analytical tool available to study chemically and physically complex systems, however the application of NMR to improve our understanding of environmental problems is underdeveloped relative to its use in other scientific disciplines. The proposed research will contribute to the growing development of environmental applications of NMR across many disciplines of environmental science, including environmental chemistry, environmental microbiology, and environmental toxicology. The proposed research program will provide academic, economic, environmental and societal benefits to Canada by providing the new tools and knowledge needed to enhance and improve our environmental practices to ensure continued access to healthy ecosystems and clean water now and in the future. Improved analytical approaches to characterize contaminated environments will assist in the design of improved models to predict molecular fate, behaviour and potential harm from contamination in the environment. These approaches will assist in the design and implementation of strategies and technologies to monitor, mitigate and remediate sensitive environmental systems.