Combined orthogonal spectroscopic analysis and chemometrics as PAT tool for calibration and self-optimizing chemical processes (NMRplusX)
正交光谱分析和化学计量学相结合,作为校准和自我优化化学过程的 PAT 工具 (NMRplusX)
基本信息
- 批准号:530118-2018
- 负责人:
- 金额:$ 4.01万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Collaborative Research and Development Grants
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The ability to visualize a chemical reaction in real-time is a very powerful and much needed tool. Real-time feedback allows chemical researchers to expedite the research and discovery process; allowing them to more rapidly identify new transformations and study new catalysts. At the same time, this technology is needed to safely control production and manufacturing processes. Many analytical techniques have been adapted to probe chemical reactions in real-time, however, most have serious restrictions on the kind of reaction that can be investigated, or require significant effort to prepare samples for visualization. This is especially true for analysis by Nuclear Magnetic Resonance (NMR). Despite the wealth of kinetic and structural information available through this technique, broad application has been hampered by the technical challenges of sampling and analysis. The challenge is to design and integrate an efficient workflow that allows any reaction to be probed quickly, accurately and with minimal perturbation of the system under study. Equally important is the software to allow seamless integration of analytical data from multiple orthogonal techniques. This project will develop new hardware and software technology through a four-part partnership between Nanalysis Corp. (NAN), Trout GmbH (TRT), the Fraunhofer Institute for Microengineering and Microsystems (IMM) and the Hein lab at the University of British Columbia (UBC). This comprehensive international team has separately demonstrated the required expertise to successfully build and deploy this ambitions technology platform.
实时可视化化学反应的能力是一个非常强大和急需的工具。实时反馈使化学研究人员能够加快研究和发现过程,使他们能够更快地识别新的转化和研究新的催化剂。与此同时,需要这项技术来安全地控制生产和制造过程。许多分析技术已被用于实时探测化学反应,然而,大多数分析技术对可以研究的反应类型有严格的限制,或者需要大量的工作来准备用于可视化的样品。这对于通过核磁共振(NMR)进行的分析尤其如此。尽管这一技术提供了丰富的动力学和结构信息,但取样和分析的技术挑战阻碍了其广泛应用。面临的挑战是设计和整合一个有效的工作流程,使任何反应都可以快速,准确地探测,并以最小的干扰下研究的系统。 同样重要的是,软件可以无缝集成来自多个正交技术的分析数据。 该项目将通过Nanalysis Corp.(NAN),Trout GmbH(TRT),Fraunhofer微工程和微系统研究所(IMM)和不列颠哥伦比亚省大学(UBC)的Hein实验室之间的四部分合作伙伴关系开发新的硬件和软件技术。这个综合性的国际团队分别展示了成功构建和部署这个雄心勃勃的技术平台所需的专业知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Hein, Jason其他文献
Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1.
- DOI:
10.1021/ja2064389 - 发表时间:
2011-11-16 - 期刊:
- 影响因子:15
- 作者:
Millward, Steven W.;Henning, Ryan K.;Kwong, Gabriel A.;Pitram, Suresh;Agnew, Heather D.;Deyle, Kaycie M.;Nag, Arundhati;Hein, Jason;Lee, Su Seong;Lim, Jaehong;Pfeilsticker, Jessica A.;Sharpless, K. Barry;Heath, James R. - 通讯作者:
Heath, James R.
Hein, Jason的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Hein, Jason', 18)}}的其他基金
Integrating automated experimentation with process analytical technology
将自动化实验与过程分析技术相结合
- 批准号:
RGPAS-2021-00016 - 财政年份:2022
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Integrating automated experimentation with process analytical technology
将自动化实验与过程分析技术相结合
- 批准号:
RGPIN-2021-03168 - 财政年份:2022
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integrating automated experimentation with process analytical technology
将自动化实验与过程分析技术相结合
- 批准号:
RGPIN-2021-03168 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Integrating automated experimentation with process analytical technology
将自动化实验与过程分析技术相结合
- 批准号:
RGPAS-2021-00016 - 财政年份:2021
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes
原位分析串联反应进展作为发现和优化合成工艺的手段
- 批准号:
RGPIN-2016-04613 - 财政年份:2020
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes
原位分析串联反应进展作为发现和优化合成工艺的手段
- 批准号:
RGPIN-2016-04613 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
Combined orthogonal spectroscopic analysis and chemometrics as PAT tool for calibration and self-optimizing chemical processes (NMRplusX)
正交光谱分析和化学计量学相结合,作为校准和自我优化化学过程的 PAT 工具 (NMRplusX)
- 批准号:
530118-2018 - 财政年份:2019
- 资助金额:
$ 4.01万 - 项目类别:
Collaborative Research and Development Grants
Combined orthogonal spectroscopic analysis and chemometrics as PAT tool for calibration and self-optimizing chemical processes (NMRplusX)
正交光谱分析和化学计量学相结合,作为校准和自我优化化学过程的 PAT 工具 (NMRplusX)
- 批准号:
530118-2018 - 财政年份:2018
- 资助金额:
$ 4.01万 - 项目类别:
Collaborative Research and Development Grants
Advanced prototype for continuous crystal sizing
用于连续晶体尺寸测量的先进原型
- 批准号:
523067-2018 - 财政年份:2018
- 资助金额:
$ 4.01万 - 项目类别:
Engage Plus Grants Program
Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes
原位分析串联反应进展作为发现和优化合成工艺的手段
- 批准号:
RGPIN-2016-04613 - 财政年份:2018
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Grants Program - Individual
相似国自然基金
数学物理中精确可解模型的代数方法
- 批准号:11771015
- 批准年份:2017
- 资助金额:48.0 万元
- 项目类别:面上项目
基于Riemann-Hilbert方法的相关问题研究
- 批准号:11026205
- 批准年份:2010
- 资助金额:3.0 万元
- 项目类别:数学天元基金项目
正交的和拟正交的空时码的最大码率与最小延迟
- 批准号:60472038
- 批准年份:2004
- 资助金额:21.0 万元
- 项目类别:面上项目
相似海外基金
Orthogonal Sensing Strategies for Soft Sensors to Discern Multiple Stimuli
软传感器识别多重刺激的正交传感策略
- 批准号:
DP240101993 - 财政年份:2024
- 资助金额:
$ 4.01万 - 项目类别:
Discovery Projects
DMS/NIGMS 1: Multilevel stochastic orthogonal subspace transformations for robust machine learning with applications to biomedical data and Alzheimer's disease subtyping
DMS/NIGMS 1:多级随机正交子空间变换,用于稳健的机器学习,应用于生物医学数据和阿尔茨海默病亚型分析
- 批准号:
2347698 - 财政年份:2024
- 资助金额:
$ 4.01万 - 项目类别:
Continuing Grant
Biotin Orthogonal Streptavidin System (BOSS) for Drug Pre-Targeting
用于药物预靶向的生物素正交链霉亲和素系统 (BOSS)
- 批准号:
10606180 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Orthogonal split luciferases for imaging multiplexed cellular behaviors
用于多重细胞行为成像的正交分裂荧光素酶
- 批准号:
10730660 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Developing an integrated pipeline for routine generation of orthogonal GPCR-targeting nanobodies
开发用于常规生成正交 GPCR 靶向纳米抗体的集成管道
- 批准号:
10603669 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
CAREER: Chemical Tools for Bio-Orthogonal Neuromodulation
职业:生物正交神经调节的化学工具
- 批准号:
2238400 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Continuing Grant
Collaborative Research: An Optimal Algorithm for Orthogonal Eigenvectors of Symmetric Tridiagonals
协作研究:对称三对角线正交特征向量的最优算法
- 批准号:
2309596 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Standard Grant
Stimuli-responsive porous soft materials by orthogonal linkage chemistries
正交连接化学刺激响应多孔软材料
- 批准号:
22KF0207 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Directed Evolution of an Orthogonal Quadruplet Codon-based Genetic Code
基于正交四联体密码子的遗传密码的定向进化
- 批准号:
EP/Y014154/1 - 财政年份:2023
- 资助金额:
$ 4.01万 - 项目类别:
Fellowship