Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes

原位分析串联反应进展作为发现和优化合成工艺的手段

• 批准号: RGPIN-2016-04613
• 负责人: Hein, Jason
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=709401
• 关键词: Tandem; Reaction; Progress; Situ; Analysis

Chemistry is, first and foremost, an observational science dedicated to explaining change with time. This research proposal applies technology and techniques developed in my group, which utilize data from real-time, in-situ monitoring to allow reactions and process to be visualized rapidly and accurately. These tools are employed in two main research areas. The first centers on the study of homogeneous catalysis, with the aim of understanding reaction mechanisms, discovering new transformations and designing more efficient chemical processes. This application both helps to discover new catalytic transformation and to optimize and refine existing protocols. The second topic focuses on studying and applying selective crystallization using a new continuous crystallization technique, allowing access to bulk quantities of enantiopure compounds. Both projects rely on the ability to quickly and easily delineate complex reaction systems using in situ analysis. Successfully achieving these research goals will dramatically change the chemical research communities approach to new reaction design, as well as delivery technology to revolutionize how enantiopure commodity chemicals are manufactured.

化学首先是一门观测科学，致力于解释随时间的变化。该研究方案应用了我的团队开发的技术和方法，利用实时原位监测的数据，使反应和过程快速准确地可视化。这些工具主要用于两个研究领域。第一个集中在均相催化的研究，目的是了解反应机理，发现新的转化和设计更有效的化学过程。该应用程序既有助于发现新的催化转化，也有助于优化和改进现有的协议。第二个主题的重点是研究和应用选择性结晶使用一种新的连续结晶技术，允许获得大量的对映体纯化合物。这两个项目都依赖于使用原位分析快速轻松地描绘复杂反应系统的能力。成功实现这些研究目标将极大地改变化学研究界对新反应设计的方法，以及彻底改变对映体纯商品化学品制造方式的交付技术。