Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes

首先，化学是一门致力于解释随时间变化的观察性科学。这项研究方案应用了我的团队开发的技术和技术，这些技术和技术利用来自实时、现场监测的数据，使反应和过程能够快速而准确地可视化。这些工具主要用于两个研究领域。第一个中心是研究均相催化，目的是了解反应机理，发现新的转化，并设计更有效的化学过程。这一应用既有助于发现新的催化转化，也有助于优化和完善现有的方案。第二个主题集中于研究和应用一种新的连续结晶技术的选择性结晶，允许获得大量的对映体化合物。这两个项目都依赖于使用现场分析快速、轻松地描绘复杂反应系统的能力。成功实现这些研究目标将极大地改变化学研究团体对新反应设计的方法，以及使对映体商品化学品的制造方式发生革命性变化的输送技术。

Chemistry is, first and foremost, an observational science dedicated to explaining change with time. This research proposal applies technology and techniques developed in my group, which utilize data from real-time, in-situ monitoring to allow reactions and process to be visualized rapidly and accurately. These tools are employed in two main research areas. The first centers on the study of homogeneous catalysis, with the aim of understanding reaction mechanisms, discovering new transformations and designing more efficient chemical processes. This application both helps to discover new catalytic transformation and to optimize and refine existing protocols. The second topic focuses on studying and applying selective crystallization using a new continuous crystallization technique, allowing access to bulk quantities of enantiopure compounds. Both projects rely on the ability to quickly and easily delineate complex reaction systems using in situ analysis. Successfully achieving these research goals will dramatically change the chemical research communities approach to new reaction design, as well as delivery technology to revolutionize how enantiopure commodity chemicals are manufactured.**