Advanced prototype for continuous crystal sizing

用于连续晶体尺寸测量的先进原型

• 批准号: 523067-2018
• 负责人: Hein, Jason
• 金额: $ 0.91万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Plus Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=653362
• 关键词: Advanced; prototype; continuous; crystal; sizing

Control of crystallite particle size distribution is essential in the manufacturing of pharmaceutical dosage**forms. In particular, obtaining a narrow size distribution is essential to enable precise control of release profile**of therapeutic agent through novel technology developed by Eupraxia pharmaceuticals. The present workflow**needed to obtain crystallite particles of the appropriate particle size presents a significant barrier to scale up and**manufacturing of a novel anti-inflammatory therapy. This proposal builds on a successful completed ENGAGE**grant and aims to codesign and qualify a novel crystal sizing apparatus. The completed device must be capable**of size segregation of a milled crystal population in a continuous workflow. This device will test the feasibility**of a novel pulse-flow sieving concept and examine the potential for scale-up and design and a large-scale unit**built for a manufacturing environment.

控制微晶粒度分布对于药物剂型的制造至关重要。特别是，获得窄的尺寸分布对于通过 Eupraxia 制药公司开发的新技术精确控制治疗剂的释放曲线**至关重要。目前的工作流程**需要获得适当粒径的微晶颗粒，这对新型抗炎疗法的规模化和**制造提出了重大障碍。该提案建立在成功完成的 ENGAGE** 资助的基础上，旨在共同设计和鉴定新型晶体尺寸测量装置。完成的设备必须能够在连续工作流程中**研磨晶体群的尺寸分离。该设备将测试新型脉冲流筛分概念的可行性**，并检查扩大规模和设计以及为制造环境构建的大型装置**的潜力。