Advanced prototype for continuous crystal sizing

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Control of crystallite particle size distribution is essential in the manufacturing of pharmaceutical dosage**forms. In particular, obtaining a narrow size distribution is essential to enable precise control of release profile**of therapeutic agent through novel technology developed by Eupraxia pharmaceuticals. The present workflow**needed to obtain crystallite particles of the appropriate particle size presents a significant barrier to scale up and**manufacturing of a novel anti-inflammatory therapy. This proposal builds on a successful completed ENGAGE**grant and aims to codesign and qualify a novel crystal sizing apparatus. The completed device must be capable**of size segregation of a milled crystal population in a continuous workflow. This device will test the feasibility**of a novel pulse-flow sieving concept and examine the potential for scale-up and design and a large-scale unit**built for a manufacturing environment.