Developing novel smart biointerfaces for in vitro biosensing and point of care diagnostics

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In this project, we propose to design a new class of immunodiagnostic-based biosensors that are more precise and functional than conventional biosensors. We will do this using our novel technique in preparation of the sensors' bio-interfaces where we utilize the lubricant-infused-surface technology in order to enhance the sensor's functionality. Our new surface modification techniques allow us to obtain surfaces that have a superior ability in detecting very low concentrations of the desired bio-species in complex environments such as blood and blood plasma. We will employ these biosensors in detecting low-molecular weight proteins such as Interleukin 6 which plays a crucial role in early detection of a variety of cancers as well as inflammatory diseases and immunotherapy. The other objective of this project is producing point-of-care diagnostic biosensors by incorporating microfluidic systems. These portable devices can facilitate the detection of the related diseases in a rapid and straightforward, yet precise manner. Creation of functional antibodies referred to as "biofunctional inks" is another goal of this proposal. This product can target a wide range of biosensor industries and biomedical applications, where sensor's robustness, ease of fabrication, and versatility are desired. We intend to commercialize our final products in collaboration with our industry partner, SQI Diagnostics Inc. We will investigate the long-term stability of the developed biosensors and determine the proper storage conditions of the products. Further, we will design high throughput production lines with in-line quality control systems for the fabrication of the biosensors and other side products.