Production of isomalto-oligosaccharides with tailored technological and nutritional functionalities

生产具有定制技术和营养功能的异麦芽低聚糖

• 批准号: 542301-2019
• 负责人: Gaenzle, Michael
• 金额: $ 8.01万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=699565
• 关键词: Production; isomalto; oligosaccharides; tailored; technological

Isomalto-oligosaccharides (IMO) are used as alternative low-calorie sweeteners in food products. Because of different methods of production and downstream purification, commercial IMO differ substantially with regards to their composition, and thus in digestibility, caloric content and utilisation by intestinal microbiota. The IMO preparation produced by BioNeutra contains isomaltose and higher a(1?6)-linked isomalto-oligosaccharides as well as panose-series oligosaccharides with a degree of polymerization of 4 - 6. IMO are partially indigestible and the undigested portion is fermented in the colon. However, current knowledge does not allow to quantify the digestible portion of isomalto-oligosaccharides and hence their caloric value; moreover, the dietary fibre content of current IMO preparations as determined by official methods is relatively low, which negatively impacts marketing claims with respect to their nutritional functionality. It is therefore the aim of this project to develop novel methods for IMO production to decrease the digestibility, and to increase the fibre content. Novel oligosaccharides will be evaluated with respect to their digestibility and with respect to their use in food applications. The project aims to meet the following specific objectives: (i) To produce IMO with increased degree of polymerization and branching, and reduced digestibility. (ii) To characterize novel IMO with instrumental and enzymatic methods. (iii) To evaluate the digestibility of IMO in animal models. The long term aim is to establish a platform for flexible production of isomalto-oligosaccharides with tailored technological and nutritional functionalities BioNeutra Inc. will benefit by establishment of improved methods for production of IMO. Moreover, scientific support for functional claims for IMO is critical for BioNeutra's efforts to enhance market access in North America and in Europe. The project will support long term manufacturing employment in Canada.

低聚异麦芽糖（IMO）在食品中用作替代低热量甜味剂。由于不同的生产方法和下游纯化，商业IMO在其组成方面存在很大差异，因此在消化率，卡路里含量和肠道微生物群的利用率方面也存在很大差异。BioNeutra生产的IMO制剂含有异麦芽糖和较高的a（1？6)-连接的异麦芽寡糖以及聚合度为4 - 6的潘糖系列寡糖。IMO是部分消化和未消化的部分是在结肠发酵。然而，目前的知识不允许量化异麦芽低聚糖的可消化部分，因此它们的热量值;此外，通过官方方法测定的当前IMO制剂的膳食纤维含量相对较低，这对关于其营养功能的市场宣传产生了负面影响。因此，本项目的目的是开发IMO生产的新方法，以降低消化率并增加纤维含量。将评价新型低聚糖的可消化性及其在食品中的应用。该项目旨在实现以下具体目标：（一）生产聚合度和支化度提高、消化性降低的IMO。(ii)用仪器和酶的方法表征新的IMO。(iii)在动物模型中评价IMO的消化率。长期目标是建立一个平台，灵活生产异麦芽低聚糖，具有定制的技术和营养功能 BioNeutra公司将受益于建立改进的IMO生产方法。此外，对IMO功能声明的科学支持对于BioNeutra加强北美和欧洲市场准入的努力至关重要。该项目将支持加拿大的长期制造业就业。