Production of isomalto-oligosaccharides with tailored technological and nutritional functionalities

生产具有定制技术和营养功能的异麦芽低聚糖

• 批准号: 542301-2019
• 负责人: Gänzle, Michael
• 金额: $ 8.01万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=692954
• 关键词: Production; isomalto; oligosaccharides; tailored; technological

Isomalto-oligosaccharides (IMO) are used as alternative low-calorie sweeteners in food products. Because of different methods of production and downstream purification, commercial IMO differ substantially with regards to their composition, and thus in digestibility, caloric content and utilisation by intestinal microbiota. The IMO preparation produced by BioNeutra contains isomaltose and higher a(1?6)-linked isomalto-oligosaccharides as well as panose-series oligosaccharides with a degree of polymerization of 4 - 6. IMO are partially indigestible and the undigested portion is fermented in the colon. However, current knowledge does not allow to quantify the digestible portion of isomalto-oligosaccharides and hence their caloric value; moreover, the dietary fibre content of current IMO preparations as determined by official methods is relatively low, which negatively impacts marketing claims with respect to their nutritional functionality. It is therefore the aim of this project to develop novel methods for IMO production to decrease the digestibility, and to increase the fibre content. Novel oligosaccharides will be evaluated with respect to their digestibility and with respect to their use in food applications. The project aims to meet the following specific objectives: (i) To produce IMO with increased degree of polymerization and branching, and reduced digestibility. (ii) To characterize novel IMO with instrumental and enzymatic methods. (iii) To evaluate the digestibility of IMO in animal models. The long term aim is to establish a platform for flexible production of isomalto-oligosaccharides with tailored technological and nutritional functionalitiesBioNeutra Inc. will benefit by establishment of improved methods for production of IMO. Moreover, scientific support for functional claims for IMO is critical for BioNeutra's efforts to enhance market access in North America and in Europe. The project will support long term manufacturing employment in Canada.

异麦芽糖寡糖（IMO）被用作食品中低热量甜味剂的替代品。由于不同的生产和下游净化方法，商业IMO在组成上存在很大差异，因此在消化率、热量含量和肠道微生物群的利用上也存在很大差异。BioNeutra生产的IMO制剂含有异麦芽糖和较高的a(1？6)-连接的异麦芽糖寡糖以及聚合度为4 - 6的聚糖系列寡糖。IMO部分难以消化，未消化的部分在结肠中发酵。然而，目前的知识不允许量化低聚异麦芽糖的可消化部分，因此它们的热值；此外，根据官方方法确定的目前国际海事组织制剂的膳食纤维含量相对较低，这对其营养功能的营销声明产生了负面影响。因此，这个项目的目的是开发新的方法来生产IMO，以降低消化率，增加纤维含量。将对新型低聚糖的消化率及其在食品中的应用进行评估。该项目旨在达到下列具体目标：(i)生产聚合和分支程度增加、可消化性降低的海事组织。用仪器和酶的方法描述新型海事组织的特征。（iii）评估IMO在动物模型中的消化率。长期目标是建立一个灵活生产具有量身定制的技术和营养功能的异麦芽糖低聚糖的平台，生物纽元公司将从建立改进的IMO生产方法中受益。此外，对IMO功能性声明的科学支持对于BioNeutra在北美和欧洲加强市场准入的努力至关重要。该项目将支持加拿大制造业的长期就业。