Point-of-care COVID-19 sensor for rapid, large-scale testing

用于快速、大规模测试的床旁 COVID-19 传感器

• 批准号: 555165-2020
• 负责人: Gupta, Manisha
• 金额: $ 3.64万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705591
• 关键词: Point; care; COVID; 19; sensor

In this study, we intend to develop an economical, repeatable, reliable, highly accurate biosensor for COVID-19 diagnostic "point-of-care" testing. The rapid transmission from asymptomatic infected people has made COVID-19 such a widespread and deadly pandemic compared to SARS or MERS. Relying on "social-distancing" measures comes at enormous economic and social cost; this type of compliance is not a sustainable long-term solution. Accurate, large-scale affordable testing is imperative until a vaccine is developed and deployed globally. Much like home pregnancy tests, the proposed portable "point-of-care" devices will use a sample (e.g. saliva) to generate immediate and highly accurate results. It will remove the time delays, high costs and bottle necks experienced with the traditional PCR-based testing methods/protocols currently being used for testing. The proposed biosensors will be printed using aerosol jet 3D printer and can economically be scaled while maintaining the quality. The sensor can be deployed quickly at workplaces, schools, hospitals, airports, etc. for immediate test results. Organic transistors work well as biosensors because they can be used in aqueous medium and also demonstrate high sensitivity. These devices are functionalized to detect COVID virus. This device will give a quick measurement of the COVID-19 virus and will use the patient saliva for testing. The device will be a single use disposable one that can be disposed safely after testing. This device will expedite the testing time and also the number of tests that can be performed which is the requirement of the day.

在这项研究中，我们打算开发一种经济、可重复、可靠、高度准确的生物传感器，用于COVID-19诊断“床旁”检测。与SARS或MERS相比，无症状感染者的快速传播使COVID-19成为如此广泛和致命的大流行病。 依赖“社交距离”措施会带来巨大的经济和社会代价;这种遵守措施不是可持续的长期解决办法。在疫苗开发和全球部署之前，必须进行准确、大规模、负担得起的测试。就像家庭怀孕测试一样，拟议中的便携式“即时护理”设备将使用样本（例如唾液）来生成即时和高度准确的结果。它将消除目前用于测试的传统基于PCR的测试方法/方案所经历的时间延迟、高成本和瓶颈。拟议的生物传感器将使用气溶胶喷射3D打印机打印，并且可以在保持质量的同时经济地扩展。该传感器可以快速部署在工作场所、学校、医院、机场等，以获得即时测试结果。 有机晶体管作为生物传感器工作良好，因为它们可以在水介质中使用，并且还表现出高灵敏度。这些设备被功能化以检测COVID病毒。该设备将快速测量COVID-19病毒，并将使用患者唾液进行测试。该器械为一次性使用器械，可在试验后安全处置。该设备将加快测试时间，也可以进行测试的数量，这是一天的要求。