Tellurium polymers as mass-tags for the detection of COVID-19 virus particles

碲聚合物作为质量标签用于检测 COVID-19 病毒颗粒

• 批准号: 554641-2020
• 负责人: Seferos, Dwight
• 金额: $ 3.64万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705620
• 关键词: Tellurium; polymers; mass; tags; detection

In this new collaboration the Seferos group will team up with Fluidigm Canada to develop polymer mass tags for viruses including Covid-19. Fluidigm has developed mass-based detection and imaging methods that are some of the most sensitive platforms on the market. Their unique instrumentation is complimentary flow cytometry, since it is more specific and has the potential for greater multiplexing. The instruments rely on polymer 'mass tags' that are bound to antibodies. The mass tags deliver specific metals to the surfaces of cell, or in this case virus particles. the labeled cells are then delivered to an inductively coupled mass spectrometry and quantified. This has profound implications for the detection of novel diseases including Covid-19. In this project the Seferos group will utilized their expertise in tellurium polymer chemistry to develop new mass-based reagents for the detection of Covid-19.

在这次新的合作中，Seferos团队将与加拿大Fluidigm公司合作，为包括Covid-19在内的病毒开发聚合物质量标签。Fluidigm开发了基于质量的检测和成像方法，是市场上最敏感的平台之一。他们独特的仪器是互补流式细胞术，因为它更具体，具有更大的复用潜力。这种仪器依赖于与抗体结合的聚合物“质量标签”。质量标签将特定的金属传递到细胞表面，或者在这种情况下是病毒颗粒。然后将标记的细胞送到电感耦合质谱仪并定量。这对检测包括Covid-19在内的新型疾病具有深远影响。在该项目中，Seferos集团将利用其在碲聚合物化学方面的专业知识开发用于检测Covid-19的新型质量基试剂。