COVID-19 anti-viral nanofibrous filtration media from renewable materials

由可再生材料制成的 COVID-19 抗病毒纳米纤维过滤介质

• 批准号: 554895-2020
• 负责人: Renneckar, Scott
• 金额: $ 3.64万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705748
• 关键词: COVID; 19; anti; viral; nanofibrous

This project aims to create anti-viral, non-woven nanofibre filtration media that effectively captures 0.3 micron sized particles with a minimum pressure drop across the filter. These two aspects create filter media that minimize respiration impedance while maximizing filtration efficiency of aerosol particles. Our research group is actively spinning nanoscale renewable fibres suitable for filtration using the biopolymer, lignin. Lignin is separated from industrial pulping operations here in Canada and previously has been reported to show anti-viral capacity. Further, modification of lignin with non-leaching quaternary ammonium polymers was previously studied by the PI's team; quaternary ammonium compounds are potent disinfectants against viruses and are used as active ingredients in Lysol wipes. These compounds can effectively deactivate coronaviruses by disrupting the outer lipid membrane. As such, our efforts are aimed to create anti-viral filtration media composed of lignin and quaternary ammonium polymers with the former sourced from a Canadian supply chain in the forest industry. The fibers can be used in conjunction with pulp fibre substrates to make renewable filtration media created within Canada. The proposal is expected to deliver a much needed renewable biopolymer-based filter that will trap and deactivate viruses such as SARS-CoV-2. Based on the outcome of this proposal, the partners will understand the critical parameters required to make these high performance renewable filters. From these technical aspects, the partners will be able to look specifically into production processes that will allow scale-up of the technology from the technical aspects, supply chain opportunity, and performance. Hence, the partner organization efforts will further advance the technology readiness level (TRL) scale to the next gate, as well as, seek and connect businesses for supply of filtration media. Together this team has all the components to quickly develop a Canadian-supplied, high performance, renewable filter with anti-viral properties to fight this pandemic.

该项目旨在创造抗病毒、无纺布纳米纤维过滤介质，以最小的压降有效捕获0.3微米大小的颗粒。这两个方面创造了过滤介质，最大限度地减少呼吸阻抗，同时最大限度地提高气溶胶颗粒的过滤效率。我们的研究小组正在积极地纺丝纳米级可再生纤维，适合使用生物聚合物木质素进行过滤。木质素是从加拿大的工业制浆作业中分离出来的，以前有报道称木质素具有抗病毒能力。此外，PI的团队先前研究了用非浸出季铵聚合物改性木质素；季铵盐化合物是有效的病毒消毒剂，是来苏湿巾的有效成分。这些化合物可以通过破坏外脂膜有效地灭活冠状病毒。因此，我们的努力旨在创造由木质素和季铵聚合物组成的抗病毒过滤介质，前者来自加拿大森林工业供应链。该纤维可与纸浆纤维基材结合使用，在加拿大制造可再生过滤介质。该提案有望提供一种急需的可再生生物聚合物过滤器，用于捕获和灭活SARS-CoV-2等病毒。