COVID-19 anti-viral nanofibrous filtration media from renewable materials

由可再生材料制成的 COVID-19 抗病毒纳米纤维过滤介质

• 批准号: 554895-2020
• 负责人: Renneckar, Scott
• 金额: $ 3.64万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705748
• 关键词: COVID; 19; anti; viral; nanofibrous

This project aims to create anti-viral, non-woven nanofibre filtration media that effectively captures 0.3 micron sized particles with a minimum pressure drop across the filter. These two aspects create filter media that minimize respiration impedance while maximizing filtration efficiency of aerosol particles. Our research group is actively spinning nanoscale renewable fibres suitable for filtration using the biopolymer, lignin. Lignin is separated from industrial pulping operations here in Canada and previously has been reported to show anti-viral capacity. Further, modification of lignin with non-leaching quaternary ammonium polymers was previously studied by the PI's team; quaternary ammonium compounds are potent disinfectants against viruses and are used as active ingredients in Lysol wipes. These compounds can effectively deactivate coronaviruses by disrupting the outer lipid membrane. As such, our efforts are aimed to create anti-viral filtration media composed of lignin and quaternary ammonium polymers with the former sourced from a Canadian supply chain in the forest industry. The fibers can be used in conjunction with pulp fibre substrates to make renewable filtration media created within Canada. The proposal is expected to deliver a much needed renewable biopolymer-based filter that will trap and deactivate viruses such as SARS-CoV-2. Based on the outcome of this proposal, the partners will understand the critical parameters required to make these high performance renewable filters. From these technical aspects, the partners will be able to look specifically into production processes that will allow scale-up of the technology from the technical aspects, supply chain opportunity, and performance. Hence, the partner organization efforts will further advance the technology readiness level (TRL) scale to the next gate, as well as, seek and connect businesses for supply of filtration media. Together this team has all the components to quickly develop a Canadian-supplied, high performance, renewable filter with anti-viral properties to fight this pandemic.

该项目旨在创建抗病毒，无编织的纳米纤维过滤介质，该介质有效地捕获了0.3微米尺寸的颗粒，并在整个滤镜上降低了最小的压降。这两个方面产生了过滤介质，可最大程度地减少呼吸阻抗，同时最大化气溶胶颗粒的过滤效率。 我们的研究小组正在积极旋转适合使用生物聚合物木质素过滤的纳米级可再生纤维。木质素与加拿大的工业制浆作业分开，以前据报道显示抗病毒能力。此外，PI的团队先前研究了使用非凹季铵聚合物修饰木质素。第四纪铵化合物是对病毒的有效消毒剂，被用作Lysol湿巾中的活性成分。这些化合物可以通过破坏外脂质膜有效地停用冠状病毒。因此，我们的努力旨在创建由木质素和第四纪铵聚合物组成的抗病毒过滤介质，前者来自森林行业的加拿大供应链。这些纤维可与纸浆纤维底物结合使用，以使可再生过滤介质在加拿大创建。该提案有望提供急需的可再生聚合物过滤器，该过滤器将捕获并停用SARS-COV-2等病毒。 根据该提案的结果，合作伙伴将了解制造这些高性能可再生过滤器所需的关键参数。从这些技术方面，合作伙伴将能够专门研究生产过程，这些过程将使技术从技术方面，供应链机会和性能扩展。因此，合作伙伴组织的努力将进一步将技术准备水平（TRL）规模提高到下一个大门，并寻求并连接企业以供应过滤媒体。该团队共同拥有所有组件，可以迅速开发出具有抗病毒特性的加拿大供应，高性能的可再生过滤器，以抗击这一大流行。