Sewershed surveillance of COVID-19 in the City of Toronto

多伦多市下水道内的 COVID-19 监测

• 批准号: 555041-2020
• 负责人: Oswald, Claire
• 金额: $ 3.64万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=705753
• 关键词: Sewershed; surveillance; COVID; 19; City

Molecular methods have increasingly been employed for detection of pathogens from infectious diseases. They offer the ability to be sensitive, rapid, and quantitative analytical tools. Recent data on the current COVID-19 pandemic confirms that the Coronavirus can be shed in the stools of patients and that SARS-CoV2 (the causative agent of COVID-19) positive stool samples can present days before individuals even show clinical symptoms. Sewershed surveillance is a novel and alternative strategy for tracking pathogens and chemicals of interest that have been shed into the sewer system by human populations. Over the past several months, there has been growing global interest in using sewershed surveillance to investigate the circulation of genetic indicators of SARS-CoV-2. The goal of our partnership with Pani Energy is to initiate sewershed surveillance of SARS-CoV2 in the City of Toronto. Potential outcomes of a sewershed surveillance program in the City of Toronto include early detection of new COVID-19 outbreaks, tracking changes in COVID-19 infection trends (e.g., impacts of social and medical interventions), tracking COVID-19 prevalence in communities (e.g., identifying 'hotspots' of infection), and assessing risk to utility workers and those exposed to raw sewage. This project will have significant short- and long-term public health and economic benefits. The project will have an immediate impact on the City of Toronto's ability to track COVID-19 at a broad scale without burdening the healthcare system. Over the course of the project and beyond, the information generated will support public health officials making strategic decisions on medical and social interventions to stop the spread of COVID-19 and safely reopen the Toronto economy.

分子方法已越来越多地用于检测来自传染病的病原体。它们提供了灵敏、快速和定量分析工具的能力。关于当前COVID-19大流行的最新数据证实，冠状病毒可以在患者的粪便中脱落，并且SARS-CoV 2（COVID-19的病原体）阳性粪便样本可以在个体甚至表现出临床症状之前几天出现。下水道监测是一种新的替代战略，用于跟踪人类流入下水道系统的病原体和感兴趣的化学品。在过去的几个月里，全球对使用下水道监测来调查SARS-CoV-2遗传指标的传播越来越感兴趣。 我们与Pani Energy合作的目标是在多伦多市启动SARS-CoV 2的下水道监测。多伦多市下水道监测项目的潜在结果包括早期发现新的COVID-19疫情，跟踪COVID-19感染趋势的变化（例如，社会和医疗干预的影响），跟踪社区中的COVID-19流行情况（例如，确定感染的“热点”），并评估公用事业工人和接触未经处理的污水的人的风险。该项目将产生重大的短期和长期公共卫生和经济效益。该项目将对多伦多市大规模跟踪COVID-19的能力产生直接影响，而不会给医疗保健系统带来负担。在项目期间及以后，所产生的信息将支持公共卫生官员就医疗和社会干预措施做出战略决策，以阻止COVID-19的传播，并安全地重新开放多伦多经济。