Sensor driven serodiagnostics for infection and immunity in COVID-19

该联盟COVID-19项目将开发一种新的加拿大制造的COVID-19传感器，并很容易转化为下一个大流行病毒威胁。这一学术和产业联盟旨在提供快速周转的即时护理血清诊断测试，以保护患者和卫生保健人员。除了行业合作伙伴之外，NXTSens和MY01公司将为传感器设计和监管以及制造管道的使用提供技术支持（MY01）。免疫生物解决方案公司（Immune Biosolutions Inc .）将为该团队提供COVID刺突蛋白并提供使用咨询。该研究项目通过加速提供高质量和实时证据来支持加拿大对全球大流行的快速反应，从而更好地检测、治疗和/或管理COVID-19，从而实现了NSERC任务的所有目标。本课题旨在开发一种基于场效应晶体管（FET）的生物传感装置，通过刺突蛋白检测SARS-CoV-2。我们的系统将能够检测和确定测试液滴中IgM和IgG抗体的具体比例，并同时评估患者是否感染或免疫。该提案将使加拿大能够参与和协调国家和国际大规模试验和/或更好地实现统一的数据收集、数据共享和快速大规模评估影响。它将提供证据，为临床和卫生系统管理、公共卫生应对以及加拿大和国际范围内和跨辖区的决策和规划提供信息。

This Alliance COVID-19 project will develop a new made-in-Canada sensor for COVID-19 and is easily translatable to the next pandemic viral threat. This academic and industrial alliance aim to deliver point-of-care serodiagnostic testing with a rapid turnaround to protect both patients and health care personnel. In addition to the industry partners, NXTSens and MY01 Inc- which will provide technical support for sensor design and regulatory as well as use of their manufacturing pipeline (MY01. io)), a corporate partner in Sherbrooke, QC (Immune Biosolutions Inc- will supply the team with COVID Spike protein and consultation on use. This research project fulfills all objectives of the NSERC's mandate by accelerating the availability of high-quality and real-time evidence to support Canada's rapid response to the global pandemic in order to better detect, treat and/or manage COVID-19. Here we aim to develop a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 through the spike protein. Our system will be able to detect and determine specifically the proportion if any of IgM and IgG Abs in test droplets and assess simultaneously whether patient is infected or immunized. This proposal will enable Canadian engagement and coordination in national and international large-scale trials and/or better enable harmonized data collection, sharing of data, and rapid large-scale evaluation of impact. It will provide evidence to inform clinical and health system management and public health response, and decision-making and planning within and across jurisdictions in Canada and internationally.