Sensor driven serodiagnostics for infection and immunity in COVID-19

这个联盟COVID-19项目将开发一种新的加拿大制造的COVID-19传感器，并且可以很容易地转换为下一次大流行病毒威胁。该学术和工业联盟旨在提供快速周转的即时血清诊断检测，以保护患者和医疗保健人员。除了行业合作伙伴，NXTSens和MY 01公司-这将提供技术支持，传感器设计和监管以及使用他们的制造管道（MY 01。io）），位于舍布鲁克的公司合作伙伴，QC（免疫生物解决方案公司-将为团队提供COVID刺突蛋白和使用咨询。 该研究项目通过加速提供高质量和实时证据来支持加拿大对全球大流行的快速反应，以更好地检测，治疗和/或管理COVID-19，从而实现NSERC任务的所有目标。本研究旨在开发一种基于场效应晶体管（FET）的生物传感装置，通过刺突蛋白检测SARS-CoV-2。我们的系统将能够检测和确定特定的比例，如果任何的IgM和IgG抗体在测试液滴，并同时评估患者是否感染或免疫。 该提案将使加拿大能够参与和协调国家和国际大规模试验，并/或更好地协调数据收集、数据共享和快速大规模影响评估。它将提供证据，为临床和卫生系统管理和公共卫生反应提供信息，并在加拿大和国际上的司法管辖区内和跨司法管辖区进行决策和规划。

This Alliance COVID-19 project will develop a new made-in-Canada sensor for COVID-19 and is easily translatable to the next pandemic viral threat. This academic and industrial alliance aim to deliver point-of-care serodiagnostic testing with a rapid turnaround to protect both patients and health care personnel. In addition to the industry partners, NXTSens and MY01 Inc- which will provide technical support for sensor design and regulatory as well as use of their manufacturing pipeline (MY01. io)), a corporate partner in Sherbrooke, QC (Immune Biosolutions Inc- will supply the team with COVID Spike protein and consultation on use. This research project fulfills all objectives of the NSERC's mandate by accelerating the availability of high-quality and real-time evidence to support Canada's rapid response to the global pandemic in order to better detect, treat and/or manage COVID-19. Here we aim to develop a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 through the spike protein. Our system will be able to detect and determine specifically the proportion if any of IgM and IgG Abs in test droplets and assess simultaneously whether patient is infected or immunized. This proposal will enable Canadian engagement and coordination in national and international large-scale trials and/or better enable harmonized data collection, sharing of data, and rapid large-scale evaluation of impact. It will provide evidence to inform clinical and health system management and public health response, and decision-making and planning within and across jurisdictions in Canada and internationally.