Sensor driven serodiagnostics for infection and immunity in COVID-19

这个联盟新冠肺炎项目将为新冠肺炎开发一种新的加拿大制造的传感器，并且可以很容易地翻译为下一次大流行病毒威胁。这个学术和行业联盟的目标是提供快速周转的护理点血清诊断测试，以保护患者和卫生保健人员。除了行业合作伙伴外，NXTSens和MY01 Inc.将为传感器设计和监管以及其制造流水线(MY01)的使用提供技术支持。IO))，舍布鲁克的企业合作伙伴QC(免疫生物解决方案公司)将向该团队提供CoVID Spike蛋白质和使用咨询。这项研究项目通过加速提供高质量和实时的证据来支持加拿大对全球大流行的快速反应，从而更好地发现、治疗和/或管理新冠肺炎，从而实现了NSERC任务的所有目标。在这里，我们的目标是开发一种基于场效应晶体管(FET)的生物传感设备，用于通过Spike蛋白检测SARS-CoV-2。我们的系统将能够专门检测和确定测试液滴中是否有任何IgM和Ig G抗体的比例，并同时评估患者是否感染或免疫。这项提议将使加拿大能够参与和协调国家和国际大规模试验，和/或更好地协调数据收集、数据共享和快速大规模影响评估。它将提供证据，为临床和卫生系统管理和公共卫生响应以及加拿大和国际司法管辖区内和跨司法管辖区的决策和规划提供信息。

This Alliance COVID-19 project will develop a new made-in-Canada sensor for COVID-19 and is easily translatable to the next pandemic viral threat. This academic and industrial alliance aim to deliver point-of-care serodiagnostic testing with a rapid turnaround to protect both patients and health care personnel. In addition to the industry partners, NXTSens and MY01 Inc- which will provide technical support for sensor design and regulatory as well as use of their manufacturing pipeline (MY01. io)), a corporate partner in Sherbrooke, QC (Immune Biosolutions Inc- will supply the team with COVID Spike protein and consultation on use. This research project fulfills all objectives of the NSERC's mandate by accelerating the availability of high-quality and real-time evidence to support Canada's rapid response to the global pandemic in order to better detect, treat and/or manage COVID-19. Here we aim to develop a field-effect transistor (FET)-based biosensing device for detecting SARS-CoV-2 through the spike protein. Our system will be able to detect and determine specifically the proportion if any of IgM and IgG Abs in test droplets and assess simultaneously whether patient is infected or immunized. This proposal will enable Canadian engagement and coordination in national and international large-scale trials and/or better enable harmonized data collection, sharing of data, and rapid large-scale evaluation of impact. It will provide evidence to inform clinical and health system management and public health response, and decision-making and planning within and across jurisdictions in Canada and internationally.