Electrochemical biosensors for point-of-care diagnostics

目前用于体外和临床评估的技术是昂贵的、复杂的、劳动密集型的和耗时的。此外，由于分子诊断测试和仪器是复杂的，它们需要高度知识渊博和专家的科学家来建立基准。因此，它们不能提供真实的时间决策支持。重要的未满足的需求（我的研究计划背后的主要驱动力）是开发易于使用，快速和负担得起的电化学分析解决方案，可以很容易地在临床环境或偏远地区实施。 最近的文献表明，含有金属原子或金属簇的金属蛋白质的过度表达与人类健康和疾病有关。基于某些疾病过度表达特定金属蛋白的总体假设，以及它们的金属可以直接与电极表面相互作用并特异性地显示可逆电化学，我的目标是用创新的传感设备电化学检测这些生物标志物，以帮助临床医生做出决策。 作为功能性纳米材料合成和生物基质的专家，在这里，在未来5年内，我的研究目标将集中在1）设计和构建先进导电材料和功能界面的多功能平台，用于金属蛋白和病原体的电化学检测和监测，用于健康和环境分析和管理，2）将传统的电化学电池改造成适应体内环境的工具，以及3）评估这些创新的可植入电化学装置，以帮助疾病检测和管理，以及监测愈合。 我的研究项目为HQP提供了良好的培训环境，因为它涉及材料科学，生物医学工程，电化学等学科。通过在体内和临床环境中与真实的最终产品用户一起测试我们的电化学设备，进一步丰富了培训内容。 这项研究计划将开发医疗技术平台技术不仅对学术界和工业界都很重要。此外，它们旨在通过提供更准确和更直接的疾病和正常生理分析来减轻医疗保健服务的经济负担。

Current technologies for in vitro and clinical assessment are costly, complicated, labour intensive, and time-consuming. Additionally, since molecular diagnostic tests and instrumentation are complex, they require highly knowledgeable and expert scientists to establish benchmarks. And so, they cannot provide real time decision support. The important unmet need (the primary driver behind my research program) is to develop easy-to-use, quick, and affordable electrochemical analytical solutions that can be easily implemented in either a clinical environment or the remote areas. Recent literature has indicated that overexpression of metalloproteins proteins which contain metal atoms or clusters have been associated with human health and diseases. Based on the overall hypothesis that some diseases overexpress specific metalloproteins, and that their metals can interact directly with an electrode surface and specifically display reversible electrochemistry, I aim to electrochemically detect those biomarkers with innovative sensing devices to assist clinicians in taking decisions. As an expert in the synthesis of functional nanomaterials, and electroconductive substrate, here, over the next 5 years, my research objectives will be to focus on 1) designing and building a multifunctional platform of advanced conductive materials and functional interface for the electrochemical detection and monitoring of metalloproteins and pathogens for health and environmental analysis and management, 2) modifying traditional electrochemical cells into tools adapted to in vivo environment, and 3) evaluating these innovative implantable electrochemical devices to aid in disease detection and management, and monitoring healing. My research program provides excellent training environment for HQP due to it interdisciplinary nature involving materials science, biomedical engineering, electrochemistry. The training is further enriched by the benefit of testing our electrochemical devices in vivo and in clinical environment with real end-product users. This research program will develop medicaltech platforms technology will not only be important for both academia and industry. Further, they aim to reduce the economic burden to health care services by providing more accurate and more immediate analyses of disease and normal physiology.