Electrochemical biosensors for point-of-care diagnostics

用于即时诊断的电化学生物传感器

• 批准号: RGPIN-2020-05884
• 负责人: Merle, Geraldine
• 金额: $ 2.4万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=718059
• 关键词: Electrochemical; biosensors; point; care; diagnostics

Current technologies for in vitro and clinical assessment are costly, complicated, labour intensive, and time-consuming. Additionally, since molecular diagnostic tests and instrumentation are complex, they require highly knowledgeable and expert scientists to establish benchmarks. And so, they cannot provide real time decision support. The important unmet need (the primary driver behind my research program) is to develop easy-to-use, quick, and affordable electrochemical analytical solutions that can be easily implemented in either a clinical environment or the remote areas. Recent literature has indicated that overexpression of metalloproteins proteins which contain metal atoms or clusters have been associated with human health and diseases. Based on the overall hypothesis that some diseases overexpress specific metalloproteins, and that their metals can interact directly with an electrode surface and specifically display reversible electrochemistry, I aim to electrochemically detect those biomarkers with innovative sensing devices to assist clinicians in taking decisions. As an expert in the synthesis of functional nanomaterials, and electroconductive substrate, here, over the next 5 years, my research objectives will be to focus on 1) designing and building a multifunctional platform of advanced conductive materials and functional interface for the electrochemical detection and monitoring of metalloproteins and pathogens for health and environmental analysis and management, 2) modifying traditional electrochemical cells into tools adapted to in vivo environment, and 3) evaluating these innovative implantable electrochemical devices to aid in disease detection and management, and monitoring healing. My research program provides excellent training environment for HQP due to it interdisciplinary nature involving materials science, biomedical engineering, electrochemistry. The training is further enriched by the benefit of testing our electrochemical devices in vivo and in clinical environment with real end-product users. This research program will develop medicaltech platforms technology will not only be important for both academia and industry. Further, they aim to reduce the economic burden to health care services by providing more accurate and more immediate analyses of disease and normal physiology.

目前体外和临床评估技术昂贵、复杂、劳动密集且耗时。此外，由于分子诊断测试和仪器是复杂的，它们需要知识渊博的专家科学家来建立基准。因此，他们不能提供实时的决策支持。重要的未满足需求（我的研究计划背后的主要驱动力）是开发易于使用，快速和负担得起的电化学分析解决方案，可以在临床环境或偏远地区轻松实施。