Identification of potential market licensees for University of Toronto technology related to the process of chemo-enzymatic synthesis of glucaric acid from xylans

葡萄糖酸是一种平台化学品，是生物聚合物合成的关键组成部分，包括 生物基尼龙和超支化聚酯。葡萄糖酸也可用作无磷洗涤剂。 以及除冰剂。2016年全球葡萄糖酸市场规模估计为5.504亿美元 2018-2023年期间预计累计平均增长率(CAGR)为7%。目前， 在商业上，葡萄糖酸是通过葡萄糖的非选择性硝酸氧化合成的。 收益率约为40%。这种传统的方法存在选择性低的缺点，增加了 将葡萄糖酸从其他有机酸副产物中分离出来。或者，葡萄糖酸或其 甲基化形式(4-O-甲基D-葡萄糖酸)可由葡萄糖醛酸木聚糖产生，这是一种 相对未充分利用的木材部分和农业生物炼油厂。我们的团队建立了一个两步法， 从未充分利用的木聚糖中一锅酶法生产葡萄糖酸。新的酶法工艺具有 有潜力为满足未得到满足的市场需求作出重大贡献。因此，这个市场 评估建议书将概述一条利用主要市场研究方法衡量 跨葡萄糖酸价值链的关键参与者对这一新的酶法工艺的兴趣和水平 技术

Glucaric acid is a platform chemical that serves as a key building block for biopolymer synthesis, including bio-based nylons and hyperbranched polyesters. Glucaric acid is also used as such in phosphate-free detergents along with de-icing agents. The global glucaric acid market size was estimated at USD 550.4 million in 2016 with a projected cumulative average growth rate (CAGR) of 7% during the 2018-2023 period. Presently, glucaric acid is commercially synthesized as glucarate by the non-selective nitric acid oxidation of glucose with a yield of ca. 40 %. This conventional approach suffers from low selectivity, increasing the cost for downstream separation of glucaric acid from other organic acid by-products. Alternatively, glucaric acid or its methylated form (4-O-methyl D-glucaric acid) could be produced from glucuronoxylans, which are a comparatively underused fraction of wood and agricultural biorefineries. Our team established a two-step, one-pot enzymatic process to generate glucaric acid from underused xylans. The new enzymatic process has the potential to make a significant contribution towards meeting unmet market needs. Accordingly, this Market Assessment proposal will outline a pathway that utilizes primary market research methods for measuring the interest and level of key participants across the glucaric acid value chain for this new enzymatic process technology.