Identification of potential market licensees for University of Toronto technology related to the process of chemo-enzymatic synthesis of glucaric acid from xylans

葡糖二酸是一种平台化学品，作为生物聚合物合成的关键组成部分，包括 生物基尼龙和超支化聚酯。葡糖二酸也用于无磷酸盐洗涤剂中 沿着除冰剂。2016年全球葡糖二酸市场规模估计为5.504亿美元 预计2018-2023年期间的累计平均增长率（CAGR）为7%。目前， 葡糖二酸在商业上通过葡萄糖的非选择性硝酸氧化以葡糖二酸盐的形式合成 一个CA的产量。百分之四十这种常规方法的缺点是选择性低，增加了制备的成本。 从其它有机酸副产物中下游分离葡糖二酸。可替代地，葡糖二酸或其组合物可用于治疗糖尿病。 甲基化形式（4-O-甲基D-葡糖二酸）可以从葡糖醛酸葡聚糖产生，葡糖醛酸葡聚糖是一种 木材和农业生物精炼的相对未充分利用的部分。我们的团队建立了一个两步， 一锅酶法从未充分利用的木聚糖产生葡糖二酸。新的酶促过程具有 有可能为满足未满足的市场需求做出重大贡献。因此，这个市场 评估提案将概述一条利用主要市场研究方法来衡量 葡萄糖二酸价值链上的关键参与者对这种新酶促工艺的兴趣和水平 技术.

Glucaric acid is a platform chemical that serves as a key building block for biopolymer synthesis, including bio-based nylons and hyperbranched polyesters. Glucaric acid is also used as such in phosphate-free detergents along with de-icing agents. The global glucaric acid market size was estimated at USD 550.4 million in 2016 with a projected cumulative average growth rate (CAGR) of 7% during the 2018-2023 period. Presently, glucaric acid is commercially synthesized as glucarate by the non-selective nitric acid oxidation of glucose with a yield of ca. 40 %. This conventional approach suffers from low selectivity, increasing the cost for downstream separation of glucaric acid from other organic acid by-products. Alternatively, glucaric acid or its methylated form (4-O-methyl D-glucaric acid) could be produced from glucuronoxylans, which are a comparatively underused fraction of wood and agricultural biorefineries. Our team established a two-step, one-pot enzymatic process to generate glucaric acid from underused xylans. The new enzymatic process has the potential to make a significant contribution towards meeting unmet market needs. Accordingly, this Market Assessment proposal will outline a pathway that utilizes primary market research methods for measuring the interest and level of key participants across the glucaric acid value chain for this new enzymatic process technology.