Side-viewing endoscopic catheter with distal micro rotary scanner for minimally invasive high-resolution intraluminal imaging - Phase I

带有远端微型旋转扫描仪的侧视内窥镜导管，用于微创高分辨率管腔内成像 - 第一阶段

• 批准号: 556130-2020
• 负责人: Takahata, Kenichi
• 金额: $ 9.11万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=706074
• 关键词: Side; viewing; endoscopic; catheter; distal

Minimally invasive endoscopic catheters are becoming today's essential diagnostic tools to tackle a variety of diseases. Commercially available fiber-optic catheters are however mostly forward viewing or limited in their visibility due to stationary viewing angles. Our research team at UBC has developed a novel microactuator technology enabled by the magnetic smart fluid called ferrofluid and demonstrated its application to the distal rotary scanner for endoscopic catheters. This I2I project aims to develop a side-viewing catheter device that embeds the developed distal scanner for high-resolution endoscopic imaging with an unobstructed circumferential viewing field. The active catheter tip will enable both high-speed and stepwise scans to allow for the use of the optical coherence tomography and other imaging modalities with the catheter. The scanner will be miniaturized to achieve minimally invasive diagnosis of lesions growing in small lumen covering a wide range of organs including coronary arteries, peripheral lung, urinary system, and biliary tract. Enabling the targeted device will remove the current need for an external catheter rotation apparatus for full circumferential scanning, improving the imaging performance while potentially making the system low cost. Preliminary results showed real-time imaging and analysis with promising results using animal models and live human tissue. The current project targets at commercialization of the device, bringing it to the optical catheter market as the first of the kind with the distal side-viewing scanner.

微创内窥镜导管正在成为当今治疗各种疾病的重要诊断工具。然而，市售的光纤导管由于固定的视角而大多是向前观察的或其可见性有限。我们在UBC的研究团队开发了一种新型的微致动器技术，该技术由称为铁磁流体的磁性智能流体实现，并展示了其在内窥镜导管远端旋转扫描仪中的应用。该I2I项目旨在开发一种侧视导管器械，该器械嵌入已开发的远端扫描仪，用于高分辨率内窥镜成像，具有无障碍的圆周视场。有源导管头端将实现高速和分步扫描，以允许使用光学相干断层扫描和导管的其他成像模式。该扫描仪将被小型化，以实现对小管腔中生长的病变的微创诊断，这些病变覆盖广泛的器官，包括冠状动脉、外周肺、泌尿系统和胆道。启用目标设备将消除当前对用于全圆周扫描的外部导管旋转设备的需要，从而改善成像性能，同时潜在地使系统成本低。初步结果显示，使用动物模型和活体人体组织进行实时成像和分析，结果令人鼓舞。目前的项目目标是将该设备商业化，将其作为首个带有远端侧视扫描仪的光学导管市场。