Intelligent Ureteral Stent System for Prevention of Renal Damage

预防肾损伤的智能输尿管支架系统

• 批准号: 523795-2018
• 负责人: Takahata, Kenichi
• 金额: $ 7.36万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=666419
• 关键词: Intelligent; Ureteral; Stent; System; Prevention

At least 10% of the Canadian population (>3.5 million Canadians) will develop a kidney stone**in their life, resulting in significant patient morbidity and burden on the healthcare system. This**problem is further deteriorated as ~50% of the patients will have a repeat episode within 5**years. Most patients are treated by placing a ureteral stent, a thin hollow plastic tube, in the**ureter (the duct that bridges the kidney to the bladder) to ensure proper urine drainage past**the stone that may be blocking it. Ureteral stents are also used in cancer patients to maintain**urine flow through the ureter that may be compressed by growing tumor. The stent itself,**however, often causes an obstruction in the urine flow, by limiting the ureters wave-like**motion to push urine down to the bladder and/or by building up crystals on the stent. In such**case, the kidney swells, a condition known as hydronephrosis, which results in kidney injury**and eventual failure if left untreated. This research will develop a novel smart ureteral stent**that will continuously track renal pressure while it is indwelling, uniquely allowing for early**detection of increased pressure before damaging hydronephrosis develops. This will enable**non-invasive, quantitative, and cost-effective tracking that is currently not available via any**existing diagnostic route. The stents will be developed to function as radiofrequency**antennas, with embedded micro pressure sensors and microelectronic chips to wirelessly**sense and transmit renal pressure. The device will be prototyped using microsystems**technology available at UBC. This novel stent technology will allow kidney stone patients to**check the status using a portable monitor at home, giving an alarm for the need of further**diagnosis and necessary treatment by urologists. The research results are anticipated to**promote different types of stents and other implants to acquire perceptual features for a wide**range of medical applications beyond the urologic area.

至少有10%的加拿大人口（> 350万加拿大人）将在他们的生活中发展肾结石 **，导致显著的患者发病率和医疗保健系统的负担。由于约50%的患者将在5** 年内重复发作，该 ** 问题进一步恶化。大多数患者的治疗方法是在输尿管（连接肾脏和膀胱的管道）中放置输尿管支架（一种薄的中空塑料管），以确保尿液通过可能堵塞的结石排出。输尿管支架也用于癌症患者，以维持尿液通过输尿管的流量，因为输尿管可能被生长的肿瘤压迫。然而，支架本身经常会通过限制输尿管的波浪状运动将尿液向下推到膀胱和/或通过在支架上积聚晶体而导致尿流阻塞。在这种情况下，肾脏会肿胀，这种情况被称为肾积水，如果不及时治疗，会导致肾损伤 ** 并最终衰竭。这项研究将开发一种新型的智能输尿管支架 **，它将在留置时持续跟踪肾压，独特地允许在损害性肾积水发展之前早期 ** 检测压力增加。这将使 ** 非侵入性，定量和具有成本效益的跟踪，目前无法通过任何 ** 现有的诊断途径。这种支架将被开发成具有射频天线的功能，内置微型压力传感器和微电子芯片，以无线方式感知和传输肾压。该设备将使用UBC提供的微系统 ** 技术进行原型制作。这种新的支架技术将允许肾结石患者在家中使用便携式监视器检查状态，并在需要泌尿科医生进一步诊断和必要治疗时发出警报。研究结果有望促进不同类型的支架和其他植入物获得感知特征，用于泌尿外科领域以外的广泛医疗应用。