Bridging the scales: Modeling macroscopic imaging from microscopy
弥合尺度:通过显微镜对宏观成像进行建模
基本信息
- 批准号:RGPIN-2017-06140
- 负责人:
- 金额:$ 5.1万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2020
- 资助国家:加拿大
- 起止时间:2020-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This NSERC proposal aims to develop novel technology to measure and model oxygen delivery in complex and realistic environments. We will develop combined 3-photon and Optical Coherence Tomography (OCT) microscopy imaging to assess in vivo, how vascular topology and RBC dynamics change neural tissue oxygenation. Using measures of microvascular topology, blood flow and oxygen in brain tissue, we will build and validate first-principles physics-based mechanistic models describing oxygen delivery to tissue based on advection/diffusion equations. These models will serve to simulate the physics of macroscopic signals measured with Magnetic Resonance Imaging. As a secondary stream of investigation, we aim to develop tools to investigate structural correlates of impaired oxygen delivery. A custom imaging system will be designed to obtain large tissue section datasets ex vivo in 3D. Image processing tools to co-register whole brain microscopic 3D renderings to in vivo MRI images and to segment vascular and white-matter descriptors will be developed. They will be used to validate and model novel MRI white-matter measures with microscopy with the aim of refining the potential of MRI as an imaging tool. Large-scale microscopy can bridge spatial scales between imaging cellular composition and MRI and our program will lead to a realistic modeling framework to enable this bridge across scales.
该NSERC提案旨在开发新技术,以测量和模拟复杂和现实环境中的氧气输送。我们将开发组合的3光子和光学相干断层扫描(OCT)显微成像,以评估在体内,血管拓扑结构和红细胞动力学如何改变神经组织的氧合。使用脑组织中的微血管拓扑结构,血流和氧气的测量,我们将建立和验证基于第一原理物理学的机械模型,描述基于平流/扩散方程的组织氧气输送。这些模型将用于模拟磁共振成像测量的宏观信号的物理特性。作为研究的次要内容,我们的目标是开发工具来研究氧气输送受损的结构相关性。定制成像系统将被设计为在3D中获得离体大组织切片数据集。将开发图像处理工具,以将全脑显微镜3D渲染与体内MRI图像配准,并分割血管和白质描述符。他们将被用来验证和模拟新的MRI白质措施与显微镜,目的是完善MRI作为成像工具的潜力。大型显微镜可以在成像细胞组成和MRI之间架起空间尺度的桥梁,我们的计划将导致一个现实的建模框架,以实现跨尺度的桥梁。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lesage, Frederic其他文献
TAVI-PREP: A Deep Learning-Based Tool for Automated Measurements Extraction in TAVI Planning.
- DOI:
10.3390/diagnostics13203181 - 发表时间:
2023-10-11 - 期刊:
- 影响因子:3.6
- 作者:
Santalo-Corcoy, Marcel;Corbin, Denis;Tastet, Olivier;Lesage, Frederic;Modine, Thomas;Asgar, Anita;Ben Ali, Walid - 通讯作者:
Ben Ali, Walid
Longitudinal optical coherence tomography imaging of tissue repair and microvasculature regeneration and function after targeted cerebral ischemia
- DOI:
10.1117/1.jbo.25.4.046002 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:3.5
- 作者:
Lu, Yuankang;Lu, Xuecong;Lesage, Frederic - 通讯作者:
Lesage, Frederic
Characterization of the hemodynamic response in the rat lumbar spinal cord using intrinsic optical imaging and laser speckle
- DOI:
10.1016/j.jneumeth.2010.06.012 - 发表时间:
2010-08-30 - 期刊:
- 影响因子:3
- 作者:
Brieu, Nicolas;Beaumont, Eric;Lesage, Frederic - 通讯作者:
Lesage, Frederic
Low-Noise, High-Gain Transimpedance Amplifier Integrated With SiAPD for Low-Intensity Near-Infrared Light Detection
- DOI:
10.1109/jsen.2013.2282624 - 发表时间:
2014-01-01 - 期刊:
- 影响因子:4.3
- 作者:
Kamrani, Ehsan;Lesage, Frederic;Sawan, Mohamad - 通讯作者:
Sawan, Mohamad
Voluntary exercise increases brain tissue oxygenation and spatially homogenizes oxygen delivery in a mouse model of Alzheimer's disease
- DOI:
10.1016/j.neurobiolaging.2019.11.015 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:4.2
- 作者:
Lu, Xuecong;Moeini, Mohammad;Lesage, Frederic - 通讯作者:
Lesage, Frederic
Lesage, Frederic的其他文献
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{{ truncateString('Lesage, Frederic', 18)}}的其他基金
Bridging the scales: Modeling macroscopic imaging from microscopy
弥合尺度:通过显微镜对宏观成像进行建模
- 批准号:
RGPIN-2017-06140 - 财政年份:2022
- 资助金额:
$ 5.1万 - 项目类别:
Discovery Grants Program - Individual
Bridging the scales: Modeling macroscopic imaging from microscopy
弥合尺度:通过显微镜对宏观成像进行建模
- 批准号:
RGPIN-2017-06140 - 财政年份:2021
- 资助金额:
$ 5.1万 - 项目类别:
Discovery Grants Program - Individual
Canadian Research Chair In Vascular Optical Imaging
加拿大血管光学成像研究主席
- 批准号:
CRC-2014-00034 - 财政年份:2021
- 资助金额:
$ 5.1万 - 项目类别:
Canada Research Chairs
Canadian Research Chair in Vascular Optical Imaging
加拿大血管光学成像研究主席
- 批准号:
CRC-2014-00034 - 财政年份:2020
- 资助金额:
$ 5.1万 - 项目类别:
Canada Research Chairs
Improving the identification of retinal biomarkers of Alzheimer disease in vivo
提高阿尔茨海默病视网膜生物标志物的体内鉴定
- 批准号:
523599-2018 - 财政年份:2019
- 资助金额:
$ 5.1万 - 项目类别:
Collaborative Health Research Projects
Bridging the scales: Modeling macroscopic imaging from microscopy
弥合尺度:通过显微镜对宏观成像进行建模
- 批准号:
RGPIN-2017-06140 - 财政年份:2019
- 资助金额:
$ 5.1万 - 项目类别:
Discovery Grants Program - Individual
Integrated time-domain micro-optode to facilitate long-term clinical NIRS
集成时域微光极促进长期临床 NIRS
- 批准号:
523662-2018 - 财政年份:2019
- 资助金额:
$ 5.1万 - 项目类别:
Collaborative Health Research Projects
Canadian Research Chair in Vascular Optical Imaging
加拿大血管光学成像研究主席
- 批准号:
CRC-2014-00034 - 财政年份:2019
- 资助金额:
$ 5.1万 - 项目类别:
Canada Research Chairs
Improving the identification of retinal biomarkers of Alzheimer disease in vivo
提高阿尔茨海默病视网膜生物标志物的体内鉴定
- 批准号:
523599-2018 - 财政年份:2018
- 资助金额:
$ 5.1万 - 项目类别:
Collaborative Health Research Projects
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