Improving the identification of retinal biomarkers of Alzheimer disease in vivo

点击翻译按钮获取中文摘要

Alzheimers disease is a slowly evolving neurodegenerative disorder that ultimately leading to**dementia. It is the most common cause of dementia, affecting millions worldwide, with no cure**available at this time. One of the main issues with developing new therapies is the fact that**Alzheimer is usually diagnosed based on cognitive impairments, a diagnosis made late in the**evolution of the disease. This proposal aims to develop a non-invasive detection tool**exploiting commonalities between Alzheimer biomarkers present both in the brain and the**eye. Our main goal is to identify signs of the disease earlier using a test that could be done**routinely during an ophthalmology examination. We will develop methods combining**multispectral retinal imaging with image processing to identify biomarkers of amyloid plaque**accumulation in the retina and correlate results with brain PET amyloid imaging.