Sparse integrated computational optical imaging systems

稀疏集成计算光学成像系统

• 批准号: RGPIN-2018-06453
• 负责人: Sherif, Sherif
• 金额: $ 2.04万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=712985
• 关键词: Sparse; integrated; computational; optical; imaging

Integrated Computational Optical Imaging (ICOI) is a highly promising approach that involves the joint design of modified optical hardware and digital processing algorithms to achieve imaging performance, e.g., high resolution, large field-of-view, high frame rates, that would otherwise be unattainable by the unmodified system. To overcome bandwidth limitations (spatial Optical coherence tomography (OCT) is an important sub-surface imaging modality for numerous medical and industrial applications. It has one to two orders of magnitude higher resolution than ultrasound and typical imaging depth of (~ 2 mm) in biological tissue. 1. Develop a real-time submicron-resolution compressed sensing full field OCT system 2. Develop 10 times) of high NA (magnification) microscope 4. Generalize our OCT system simulator to allow imaging with finite-width light beams. We anticipate a high impact of our proposed research because 1) our novel full field - OCT system would allow 3D cell imaging cells up to a depth of 850 µ m compared to the 100 µ m imaging depth currently allowed by confocal microscopy; 2) the ability to extend the depth-of-field of high NA (magnification) optical microscopes, without loss of lateral resolution, optical power, or objective's working distance, would have a strong positive impact on a wide variety of scientific and industrial applications; 3) we anticipate a high potential for commercialization for the proposed extended depth-of-field microscopy and the proposed real-time detector of vascular plaque w from OCT images; 4) the availability of a practical, accurate and fast computer simulator of OCT systems would be an extremely useful tool to enable and/or facilitate future design of higher performance OCT systems. The proposed research program will also create unique opportunities to train 2 Ph.D. and 2 M.Sc. and 5 undergraduate students in both theoretical and practical aspects of Imaging Systems, Optics, Data Acquisition, Image Processing and Advanced Computing.

集成计算光学成像（ICOI）是一种非常有前途的方法，其涉及修改的光学硬件和数字处理算法的联合设计以实现成像性能，例如，高分辨率、大视场、高帧速率，这些是未修改的系统无法达到的。 要克服带宽限制（空间 光学相干断层成像（OCT）是用于许多医学成像的重要的亚表面成像模式。 和工业应用。它的分辨率比超声波高一到两个数量级 并且在生物组织中的典型成像深度为（~ 2 mm）。 1.实时亚微米分辨率压缩传感全场OCT系统的研制 2.高NA（放大倍数）显微镜的10倍 4.推广我们的OCT系统模拟器，以允许使用有限宽度光束进行成像。 我们预计我们提出的研究将产生很大的影响，因为1）我们的新型全视野OCT系统将允许3D细胞成像细胞达到850 µ m的深度，而目前共聚焦显微镜允许的成像深度为100 µ m; 2）扩展高NA的景深的能力（放大）光学显微镜，而不会损失横向分辨率、光功率或物镜的工作距离，将对各种科学和工业应用产生强烈的积极影响; 3）我们预计所提出的扩展景深显微镜和所提出的来自OCT图像的血管斑块的实时检测器的商业化的高潜力; 4）OCT系统的实用、准确和快速的计算机模拟器的可用性将是实现和/或促进更高性能OCT系统的未来设计的极其有用的工具。 拟议的研究计划还将创造独特的机会，培养2名博士。以及2名硕士和5名本科生，他们在成像系统、光学、数据采集、图像处理和高级计算的理论和实践方面都有研究。