Sparse integrated computational optical imaging systems

集成计算光学成像（ICOI）是一种非常有前途的方法，其涉及修改的光学硬件和数字处理算法的联合设计以实现成像性能，例如，高分辨率、大视场、高帧速率，这是未经修改的系统无法实现的。*为了克服带宽限制（空间 *），光学相干断层扫描（OCT）是许多医疗 * 和工业应用的重要次表面成像模式。它的分辨率比超声波 * 高一到两个数量级，在生物组织中的典型成像深度为（~ 2 mm）。1.开发实时亚微米分辨率压缩感知全场OCT系统 *2.高NA（放大倍数）显微镜 *4。推广我们的OCT系统模拟器，以允许使用有限宽度光束进行成像。**我们预计我们提出的研究将产生很大的影响，因为1）我们的新型全视野OCT系统将允许3D细胞成像细胞达到850 µ m的深度，而目前共聚焦显微镜允许的成像深度为100 µ m; 2）扩展高NA景深的能力（放大）光学显微镜，而不会损失横向分辨率、光功率或物镜的工作距离，将对各种科学和工业应用产生强烈的积极影响; 3）我们预计所提出的扩展景深显微镜和所提出的来自OCT图像的血管斑块的实时检测器的商业化的高潜力; 4）OCT系统的实用、准确和快速的计算机模拟器的可用性将是实现和/或促进更高性能OCT系统的未来设计的极其有用的工具。 ** 拟议的研究计划还将创造独特的机会，培养2名博士。以及2名硕士和5名本科生，涉及成像系统、光学、数据采集、图像处理和高级计算的理论和实践方面。* **

Integrated Computational Optical Imaging (ICOI) is a highly promising approach that involves the joint design of modified optical hardware and digital processing algorithms to achieve imaging performance, e.g., high resolution, large field-of-view, high frame rates, that would otherwise be unattainable by the unmodified system.******To overcome bandwidth limitations (spatial ******Optical coherence tomography (OCT) is an important sub-surface imaging modality for numerous medical ***and industrial applications. It has one to two orders of magnitude higher resolution than ultrasound ***and typical imaging depth of (~ 2 mm) in biological tissue.******1. Develop a real-time submicron-resolution compressed sensing full field OCT system ***2. Develop 10 times) of high NA (magnification) microscope***4. Generalize our OCT system simulator to allow imaging with finite-width light beams.******We anticipate a high impact of our proposed research because 1) our novel full field - OCT system would allow 3D cell imaging cells up to a depth of 850 µ m compared to the 100 µ m imaging depth currently allowed by confocal microscopy; 2) the ability to extend the depth-of-field of high NA (magnification) optical microscopes, without loss of lateral resolution, optical power, or objective's working distance, would have a strong positive impact on a wide variety of scientific and industrial applications; 3) we anticipate a high potential for commercialization for the proposed extended depth-of-field microscopy and the proposed real-time detector of vascular plaque w from OCT images; 4) the availability of a practical, accurate and fast computer simulator of OCT systems would be an extremely useful tool to enable and/or facilitate future design of higher performance OCT systems. ******The proposed research program will also create unique opportunities to train 2 Ph.D. and 2 M.Sc. and 5 undergraduate students in both theoretical and practical aspects of Imaging Systems, Optics, Data Acquisition, Image Processing and Advanced Computing.********************************* **