Measurement of joint mechanics with novel imaging methods

用新颖的成像方法测量关节力学

• 批准号: RGPIN-2019-06347
• 负责人: Wilson, David
• 金额: $ 3.35万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=716007
• 关键词: Measurement; joint; mechanics; novel; imaging

Recent Progress: In the last six years, my HQP and I have 1) developed a nondestructive approach for mapping cartilage stiffness in the intact knee and thumb based on contrast-enhanced computed tomography (CECT); 2) developed and applied tools to predict load transmission through the subchondral bone of the knee; and 3) developed and assessed a new method for measuring hip cartilage strain that does not require disruption of any hip structures. Objectives: The long-term objectives of this program of research are to develop methods to assess joint mechanics under physiological conditions and to apply these methods to understand natural variation in joint mechanics and how the individual joint structures contribute to overall joint mechanical function. Within this program, our short-term objectives include: Aim 1: Determine the effect of anatomical variation on cartilage strain in hip specimens at physiological loads and associations with bone and cartilage stiffness; Aim 2: Determine the relationship between stiffness and CECT attenuation in hip cartilage; and Aim 3: Determine links between CT attenuation and stiffness of hip subchondral bone. Methods: We will image 20 cadaver hip specimens in the Canadian Light Source synchrotron. A cationic contrast agent (CA4+) will be injected and allowed to distribute within the cartilage. Specimens will be imaged at three load/position combinations using a loading rig. Cartilage strain will be found from the change in cartilage thickness. Specimens will then be disarticulated and hip joint surfaces will be divided into sections. Cartilage and subchondral bone stiffness will be assessed across the joint surfaces using a Mach 1 indentation testing system. Subchondral bone density maps will be determined from baseline synchrotron images using a calibrated phantom. The association between CECT attenuation in cartilage and cartilage stiffness, and between subchondral bone mineral density and stiffness will be determined. Finite element models will be developed, validated and used to predict stress/strain in the subchondral bone. HQP: This study will provide excellent training in biomechanics, imaging and image processing to a diverse group of 4 MASc, 1 PhD and 5 Undergraduate students. The training environment and opportunities will produce successful scientists, entrepeneurs and engineers for industry and academic environments as we have in the past six years. Impact: This program of research will contribute an enhanced understanding of normal hip joint biomechanics and new tools for assessing hip biomechanics nondestructively.

最近的进步：在过去的六年中，我和我的HQP有1）开发了一种非破坏性方法，用于根据对比增强的计算机断层扫描（CECT）基于对比度增强的计算机断层扫描（CECT）来映射完整膝盖和拇指的软骨刚度； 2）开发和应用工具，以预测通过膝盖下骨的负载传递； 3）开发并评估了一种测量不需要任何髋关节结构的新方法，用于测量髋部软骨菌株。 目标：该研究计划的长期目标是开发在生理条件下评估关节力学的方法，并应用这些方法来了解关节力学的自然变异以及单个关节结构如何促进整体联合力学功能。 在该程序中，我们的短期目标包括：目标1：确定解剖学变异对髋关节标本在生理载荷以及与骨骼和软骨刚度关联下的髋关节菌株的影响； 目标2：确定刚度与髋部软骨中衰减的关系；和目标3：确定CT衰减与髋骨下骨的刚度之间的联系。 方法：我们将在加拿大光源同步子中对20个尸体髋关节样品进行映像。 阳离子对比剂（CA4+）将被注入并允许在软骨内分布。 标本将使用加载钻机以三个负载/位置组合成像。 软骨厚度的变化将发现软骨应变。 然后，标本将被脱落，髋关节表面将分为部分。 软骨和软骨下骨刚度将使用Mach 1凹痕测试系统在关节表面进行评估。 软骨下骨密度图将使用校准的幻影从基线同步加速器图像确定。 将确定软骨和软骨刚度的CECT衰减之间的关联，以及软骨下骨矿物质密度和刚度之间的关联。 有限元模型将被开发，验证和用于预测软骨下骨的应力/应变。 HQP：这项研究将为4个MASC，1位博士学位和5名本科生的多样化组提供出色的生物力学，成像和图像处理培训。 培训环境和机会将与过去六年一样，为行业和学术环境提供成功的科学家，企业家和工程师。 影响：该研究计划将有助于增强对正常髋关节关节生物力学和新工具的理解，以评估髋关节生物力学无损。