The neural mechanisms underlying the promotion of motor learning by acute exercise

急性运动促进运动学习的神经机制

• 批准号: RGPIN-2020-05263
• 负责人: Neva, Jason
• 金额: $ 2.04万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=716042
• 关键词: neural; mechanisms; underlying; promotion; motor

A growing body of literature demonstrates that acute aerobic exercise (AEX) promotes motor skill learning and alters neuroplasticity-like mechanisms in the motor cortex. It is thought that these changes in neuroplasticity underlie the facilitation of skill acquisition and motor learning, yet no data links the modulation of brain and behaviour due to priming' AEX. As a consequence, knowledge of the neural mechanisms supporting the effects of AEX is incomplete. The current lack of knowledge stems in part from a notable absence of investigation into: i) the key brain regions and circuits supporting the AEX-induced effects to neuroplasticity, and ii) the influence of skill level on motor learning tasks primed' by AEX. These fundamental questions motivate the proposed research program. Recent advances in technology and research have afforded the potential to measure distinct cortical interneurons in the brain, and specifically within the motor cortex. Two distinct sets of cortical interneurons can be assessed using transcranial magnetic stimulation (TMS). My recent work, along with others, demonstrates that these interneuron populations respond uniquely to motor behaviour and repetitive TMS protocols designed to alter cortical excitability. Accumulating evidence suggests that AEX impacts motor cortex excitability, yet taken together the evidence is lacking and contradictory. My work, along with others, is suggestive that AEX may uniquely modulate motor cortical interneurons, yet no work has directly tested this question. My recent work suggests that prefrontal, parietal and cerebellar circuits contribute to motor cortex excitability change following AEX. This is bolstered by my work demonstrating AEX simultaneously improves reaching accuracy and accelerates reaction time at a skilled visuomotor task, suggesting an interactive enhancement of cognitive strategy and sensorimotor execution. Since the early stages of motor skill acquisition involves increased activity in frontal, parietal and cerebellar regions, it follows that AEX would facilitate these circuits to promote motor learning. Therefore, the current proposal will investigate the associations between: motor, prefrontal, parietal and cerebellar circuit modulation with the influence of skill in motor learning tasks primed' by AEX. This research program will be the first to uncover the critical brain regions and circuits impacted by AEX to support enhanced skill acquisition and motor learning. My proposed work represents a unique opportunity to develop our knowledge of AEX-induced neuroplasticity by capitalizing on advanced techniques of brain stimulation. It is anticipated that the results of this research program will contribute to novel and improved understanding of the neural and behavioural mechanisms underlying the impact of AEX on motor learning.

越来越多的文献表明，急性有氧运动（AEX）促进运动技能的学习和改变运动皮层的神经可塑性样机制。人们认为，这些神经可塑性的变化是促进技能获得和运动学习的基础，但没有数据链接的大脑和行为的调制，由于启动“AEX”。因此，支持AEX效应的神经机制的知识是不完整的。目前缺乏知识的部分原因是缺乏对以下方面的调查：i）支持AEX诱导的神经可塑性效应的关键脑区和回路，以及ii）技能水平对AEX引发的运动学习任务的影响。这些基本问题激发了拟议的研究计划。 技术和研究的最新进展提供了测量大脑中不同皮层中间神经元的潜力，特别是在运动皮层中。两组不同的皮质中间神经元可以使用经颅磁刺激（TMS）进行评估。我最近的工作，沿着其他人，证明了这些中间神经元群体对运动行为和旨在改变皮层兴奋性的重复TMS协议的独特反应。越来越多的证据表明，AEX影响运动皮层的兴奋性，但综合起来的证据是缺乏和矛盾的。我的工作，沿着与其他人，是暗示，AEX可能独特地调节运动皮层中间神经元，但没有工作直接测试这个问题。 我最近的工作表明，前额叶，顶叶和小脑回路有助于运动皮层兴奋性变化后AEX。这是支持我的工作证明AEX同时提高达到准确性和加速反应时间在熟练的视觉任务，这表明认知策略和感觉运动执行的互动增强。由于运动技能获得的早期阶段涉及额叶，顶叶和小脑区域的活动增加，因此AEX将促进这些回路以促进运动学习。因此，目前的建议将调查之间的关联：运动，前额叶，顶叶和小脑回路调制与技能的影响，在运动学习任务启动的AEX。 这项研究计划将首次揭示AEX影响的关键大脑区域和回路，以支持增强技能获取和运动学习。我提出的工作代表了一个独特的机会，通过利用先进的脑刺激技术来发展我们对AEX诱导的神经可塑性的知识。预计这项研究计划的结果将有助于对AEX对运动学习影响的神经和行为机制的新的和更好的理解。