Nanoparticle based measurement platforms and advanced materials

该计划旨在利用纳米科学和纳米材料的独特性质来开发新的分析测量平台。 该计划的长期目标是为环境和医疗应用以及大麻行业建立基于纳米材料的传感平台。 将在材料合成和生物测定设计领域开展一系列项目。 我们项目的核心是一种从植物中提取的绿色纳米材料。 纳米纤维素材料可以从木浆中生产，其应用可以振兴林业。 本文提出的所有测量策略都将利用贵金属纳米颗粒的尺寸依赖性光学性质。 这些纳米颗粒将附着在纳米纤维素材料上，以便将整个结构保持在水中。 所得等离子体材料将被结合到基于拉曼光谱，具体地，表面增强拉曼散射（Sers）的检测平台中。 Sers中的表面增强需要通常附着到沉积在固体表面上的纳米尺寸的金属结构。 可分散在水溶液中的Sers基底的探索不太普遍。 由于溶液的均匀性和分析物向纳米颗粒的三维扩散，水分散性基底提供了更好的再现性和更快的分析时间。 我们将专注于等离子体纳米纤维素纤维素材料的合成，作为基于溶液的Sers基底的应用。随着纳米纤维素作为金属纳米粒子的支持，我们将开发一种水分散的Sers基底，其中的重现性取决于溶液的均匀性。具体而言，纤维素纳米纤维（CNF）和纤维素纳米晶体（CNC）将被银和金纳米颗粒修饰。我们的假设是，用金属纳米颗粒均匀装饰的CNF将提供彼此紧密接近的纳米颗粒网络。我们将通过纳米纤维上的尺寸和覆盖来优化纳米颗粒沉积，以控制Sers增强。我们将根据CNF表面功能化和反应条件沿着以及它们相应的Sers信号来表征这种基底。该基底将用于对水溶性污染物进行灵敏和可重复的分析，并与手持式拉曼探针结合，为环境、医疗和大麻监测应用提供移动的平台。

This program seeks to exploit nanoscience and the unique properties of nanomaterials to develop new analytical measurement platforms. The long-range goals of the program are the establishment of nanomaterial-based sensing platforms for environmental and medical applications as well as for the cannabis industry. A range of projects will be undertaken in the areas of materials synthesis and bioassay design. At the heart of our projects is a green nanomaterial derived from plants. Nanocellulose materials can be produced from wood pulp and their applications can revitalize the forestry industry. All measurement strategies proposed here will exploit the size-dependent optical properties of noble metal nanoparticles. These nanoparticles will be attached to the nanocellulose material in order to maintain the entire construct in water. The resultant plasmonic materials will be incorporated into a detection platform based on Raman spectroscopy, specifically, surface enhanced Raman scattering (SERS). The surface enhancement in SERS requires nanosized metal structures that are generally attached to deposited on a solid surface. The exploration of SERS substrates that are dispersible in aqueous solutions has been less widespread. A water dispersible substrate offers better reproducibility and faster analysis time because of solution homogeneity and three-dimensional diffusion of the analyte to the nanoparticle. We will focus on the synthesis of plasmonic nanocellulose cellulose materials for applications as solution-based SERS substrates. With nanocellulose acting as a support for metal nanoparticles, we will develop a water dispersible SERS substrate where the reproducibility is dependent on solution homogeneity. Specifically, cellulose nanofibers (CNF) and cellulose nanocrystals (CNC) will decorated with silver and gold nanoparticles. Our hypothesis is that CNF uniformly decorated with metal nanoparticles will provide a network of nanoparticles in close proximity to each other. We will optimize the nanoparticle deposition via size and coverage on the nanofibers to control the SERS enhancement. We will characterize this substrate in terms of CNF surface functionalization and reaction conditions along with their corresponding SERS signal. This substrate will be targeted at providing sensitive and reproducible analysis of water-soluble contaminants and combined with a hand-held Raman probe to provide a mobile platform for environmental, medical and cannabis monitoring applications.