Devices and procedures to quantify radiation quality effects in radiotherapy

量化放射治疗中辐射质量影响的设备和程序

• 批准号: 435608-2013
• 负责人: Sarfehnia, Arman
• 金额: $ 2.33万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=719108
• 关键词: Devices; procedures; quantify; radiation; quality

The goal of radiation therapy is to use radiation to damage tumor cells to an extent that they are either dead (necrotic), or not viable to reproduce (sterile). To control the amount of radiation delivered to the patient, several physical or biological quantities have been suggested and are routinely in use. Although perhaps the most relevant quantity in radiotherapy would be a measure of cell death, the current accepted quantity is physical absorbed dose to water (energy deposited per unit mass of water).Recent novel developments in radiotherapy have resulted in complex delivery systems and radiation treatment plans. At times, the complexity is such that our currently accepted dosimetric protocols and detectors prove insufficient in accurately determining the absorbed dose. Moreover, current evidence-based clinical practice in radiotherapy does not take into consideration the details of radiobiological effects on individual patient treatment plan. The goal of this project is to improve the radiation dosimetry for novel delivery methods and to eventually develop a radiotherapy treatment planning solution that is commissioned and operated based on radiobiological effectiveness of the radiation beam. As such, radiotherapy treatments will be optimized to achieve a certain distribution of cell damage based on tumour type/grade/location and normal tissue proximity. We are developing an absolute dose meter that is superior in characteristics to many of contemporary detectors. Moreover, we suggest a novel approach to measurement of radiation beam quality that indirectly relates to cell damage and paves the way towards a biological effectiveness-based treatment planning software. We will be studying the effects of various modern delivery techniques including particle therapy on radiation dosimetry and biological cell tissue damage.

放射治疗的目标是利用辐射来破坏肿瘤细胞，使其要么死亡(坏死)，要么不能繁殖(无菌)。为了控制对患者的辐射量，已经提出了几个物理量或生物量的建议，并常规使用。虽然放射治疗中最相关的量可能是细胞死亡的测量，但目前被接受的量是物理吸收剂量到水(单位质量水中沉积的能量)。最近放射治疗的新发展导致了复杂的递送系统和放射治疗计划。有时，复杂性如此之大，以至于我们目前接受的剂量学方案和探测器在准确确定吸收剂量方面被证明是不够的。此外，目前的循证放射治疗临床实践没有考虑到放射生物学对个体患者治疗计划的影响的细节。该项目的目标是改进新投放方法的辐射剂量学，并最终开发一种根据辐射束的放射生物学有效性委托和操作的放射治疗计划解决方案。因此，放射治疗将得到优化，以实现基于肿瘤类型/分级/位置和正常组织邻近程度的特定细胞损伤分布。我们正在开发一种在特性上优于许多当代探测器的绝对剂量计。此外，我们提出了一种测量辐射束质量的新方法，该方法间接与细胞损伤有关，并为基于生物有效性的治疗计划软件铺平了道路。我们将研究各种现代投放技术，包括粒子疗法对辐射剂量测定和生物细胞组织损伤的影响。