Translating Academic Discoveries in Radical-Trapping Antioxidant Chemistry to Commercial Technology Development

碳氢化合物自氧化是一种自发过程，限制了生命物质以及由其衍生的化石燃料制成的产品的寿命。基本上所有碳氢化合物产品中都添加了抗氧化剂，以减缓其通过自动氧化的降解。抗氧化剂的一个特别重要的应用是在发动机润滑油中。发动机运行过程中润滑油所暴露的高温和高压极大地促进了其氧化降解。不断提高的燃油经济性标准以及人们日益认识到我们必须最大限度地减少化石燃料消耗，需要改进抗氧化技术，而抗氧化技术在 50 年来基本保持不变。渥太华大学普拉特实验室的令人兴奋的发现有可能满足这一需求。通过改进的方法来评估测试配方的功效，可以将这些发现转化为商业产品，其中可以快速识别和优化与其他润滑剂成分的相互作用。同样，监测操作条件下抗氧化剂的命运的方法将为最大限度地延长抗氧化剂寿命的结构修饰提供见解。该提案旨在验证能够开发下一代抗氧化剂的化学工具。拟议与加拿大石油润滑剂公司 (PCL) 和润英联国际 (Infineum) 的合作伙伴关系为翻译提供了理想的平台。 PCL 是加拿大最大的成品润滑油供应商，其成品润滑油是通过将其在密西沙加生产的高度精炼基础油与抗氧化剂和其他添加剂的混合物混合而成的。润英联是世界领先的燃料和润滑油添加剂配方设计师、制造商和营销商之一，为 PCL 提供用于其重型柴油发动机油、乘用车机油和自动变速箱油的添加剂包。润英联拥有专业知识和资源，可将 Pratt 实验室的发现转化为可纳入下一代 PCL 产品的产品，不仅为加拿大带来经济效益，还有助于减少加拿大和世界各地化石燃料衍生产品的消耗。

Hydrocarbon autoxidation is a spontaneous process that limits the longevity of living matter and the products made from the fossil fuels that derive therefrom. Antioxidants are added to essentially all hydrocarbon-based products to slow their degradation via autoxidation. A particularly important application of antioxidants is in engine lubricants. The high-temperatures and pressures to which lubricants are exposed during engine operation greatly facilitates their oxidative degradation. Ever increasing fuel economy standards and growing awareness that we must minimize fossil fuel consumption necessitates improvements in antioxidant technology, which has remained largely unchanged for 50 years. Exciting discoveries in the Pratt laboratory at the University of Ottawa have the potential to address this need. Translation of these discoveries to commercial products would be enabled by improved methods to assess efficacy in test formulations where interactions with other lubricant components could be rapidly identified and optimized. Likewise, means to monitor the fate of the antioxidants under operating conditions would provide insights on structural modifications that maximize antioxidant lifetime. This proposal aims to validate chemical tools that will enable the development of the next generation of antioxidants. The proposed partnership with Petro-Canada Lubricants (PCL) and Infineum International (Infineum) provides the ideal platform for translation. PCL is Canada's largest supplier of finished lubricants, which are prepared by blending the highly refined base oils they produce in Mississauga with mixtures of antioxidants and other additives. Infineum is one of the world's leading formulators, manufacturers and marketers of fuel and lubricant additives, and supply PCL with additive packages used in their heavy duty diesel engine oils, passenger car motor oils and automatic transmission fluids. Infineum has the know-how and resources to translate discoveries made in the Pratt laboratory to products that can be incorporated into the next generation of PCL products, providing not only economic benefits to Canada, but also contributing to reduced consumption of fossil fuel-derived products here and around the world.