Translating Academic Discoveries in Radical-Trapping Antioxidant Chemistry to Commercial Technology Development

碳氢化合物自氧化是一种自发的过程，它限制了生物物质和从化石燃料中提取的产品的寿命。基本上所有烃类产品都添加了抗氧化剂，以减缓其自氧化降解。抗氧化剂在发动机润滑油中的一个特别重要的应用。润滑油在发动机运行过程中所暴露的高温和高压极大地促进了它们的氧化降解。不断提高的燃油经济性标准和越来越多的人意识到我们必须尽量减少化石燃料的消耗，这就需要对抗氧化剂技术进行改进，而这一技术50年来基本保持不变。渥太华大学普拉特实验室令人兴奋的发现有可能解决这一需求。将这些发现转化为商业产品将通过改进的方法来评估测试配方的功效，其中与其他润滑剂成分的相互作用可以快速识别和优化。同样，在操作条件下监测抗氧化剂命运的手段将提供对结构修改的见解，从而最大化抗氧化剂的使用寿命。该提案旨在验证化学工具，使下一代抗氧化剂的开发成为可能。与加拿大石油润滑油公司（PCL）和Infineum International （Infineum）拟议的合作伙伴关系为翻译提供了理想的平台。PCL是加拿大最大的成品润滑油供应商，这些成品润滑油是将他们在密西沙加生产的高度精炼的基础油与抗氧化剂和其他添加剂的混合物混合而成的。Infineum是全球领先的燃料和润滑油添加剂配方商、制造商和销售商之一，并为PCL提供用于重型柴油发动机油、乘用车机油和自动变速箱油的添加剂包。英飞凌拥有专业知识和资源，可以将普惠实验室的发现转化为可纳入下一代PCL产品的产品，不仅为加拿大带来经济效益，而且还有助于减少化石燃料衍生产品的消耗。

Hydrocarbon autoxidation is a spontaneous process that limits the longevity of living matter and the products made from the fossil fuels that derive therefrom. Antioxidants are added to essentially all hydrocarbon-based products to slow their degradation via autoxidation. A particularly important application of antioxidants is in engine lubricants. The high-temperatures and pressures to which lubricants are exposed during engine operation greatly facilitates their oxidative degradation. Ever increasing fuel economy standards and growing awareness that we must minimize fossil fuel consumption necessitates improvements in antioxidant technology, which has remained largely unchanged for 50 years. Exciting discoveries in the Pratt laboratory at the University of Ottawa have the potential to address this need. Translation of these discoveries to commercial products would be enabled by improved methods to assess efficacy in test formulations where interactions with other lubricant components could be rapidly identified and optimized. Likewise, means to monitor the fate of the antioxidants under operating conditions would provide insights on structural modifications that maximize antioxidant lifetime. This proposal aims to validate chemical tools that will enable the development of the next generation of antioxidants. The proposed partnership with Petro-Canada Lubricants (PCL) and Infineum International (Infineum) provides the ideal platform for translation. PCL is Canada's largest supplier of finished lubricants, which are prepared by blending the highly refined base oils they produce in Mississauga with mixtures of antioxidants and other additives. Infineum is one of the world's leading formulators, manufacturers and marketers of fuel and lubricant additives, and supply PCL with additive packages used in their heavy duty diesel engine oils, passenger car motor oils and automatic transmission fluids. Infineum has the know-how and resources to translate discoveries made in the Pratt laboratory to products that can be incorporated into the next generation of PCL products, providing not only economic benefits to Canada, but also contributing to reduced consumption of fossil fuel-derived products here and around the world.