Translating Academic Discoveries in Radical-Trapping Antioxidant Chemistry to Commercial Technology Development

碳氢化合物自氧化是一种自发过程，它限制了生命物质和由其衍生的化石燃料制成的产品的寿命。抗氧化剂添加到基本上所有的烃类产品，以减缓其通过自氧化降解。抗氧化剂的一个特别重要的应用是在发动机润滑剂中。在发动机运行过程中，润滑油所暴露的高温和高压极大地促进了它们的氧化降解。不断提高的燃油经济性标准和越来越多的意识，我们必须尽量减少化石燃料的消耗，有必要改善抗氧化技术，这在很大程度上保持不变，为50年。渥太华大学普拉特实验室的令人兴奋的发现有可能解决这一需求。这些发现转化为商业产品将通过改进的方法来实现，以评估测试配方中的功效，其中与其他润滑剂组分的相互作用可以快速识别和优化。同样，监测操作条件下抗氧化剂的命运的方法将提供有关使抗氧化剂寿命最大化的结构修饰的见解。该提案旨在验证能够开发下一代抗氧化剂的化学工具。与加拿大石油润滑剂公司（PCL）和英菲尼姆国际公司（Infineum）的拟议合作伙伴关系为翻译提供了理想的平台。PCL是加拿大最大的成品润滑油供应商，这些润滑油是通过将他们在密西索加生产的高度精炼基础油与抗氧化剂和其他添加剂的混合物混合而制备的。英飞凌是全球领先的燃料和润滑油添加剂配方设计师、制造商和营销商之一，为PCL提供用于其重型柴油发动机油、乘用车机油和自动变速器油的添加剂包。英飞凌拥有专业知识和资源，可以将普拉特实验室的发现转化为可以融入下一代PCL产品的产品，不仅为加拿大带来经济效益，还有助于减少加拿大和世界各地化石燃料衍生产品的消耗。

Hydrocarbon autoxidation is a spontaneous process that limits the longevity of living matter and the products made from the fossil fuels that derive therefrom. Antioxidants are added to essentially all hydrocarbon-based products to slow their degradation via autoxidation. A particularly important application of antioxidants is in engine lubricants. The high-temperatures and pressures to which lubricants are exposed during engine operation greatly facilitates their oxidative degradation. Ever increasing fuel economy standards and growing awareness that we must minimize fossil fuel consumption necessitates improvements in antioxidant technology, which has remained largely unchanged for 50 years. Exciting discoveries in the Pratt laboratory at the University of Ottawa have the potential to address this need. Translation of these discoveries to commercial products would be enabled by improved methods to assess efficacy in test formulations where interactions with other lubricant components could be rapidly identified and optimized. Likewise, means to monitor the fate of the antioxidants under operating conditions would provide insights on structural modifications that maximize antioxidant lifetime. This proposal aims to validate chemical tools that will enable the development of the next generation of antioxidants. The proposed partnership with Petro-Canada Lubricants (PCL) and Infineum International (Infineum) provides the ideal platform for translation. PCL is Canada's largest supplier of finished lubricants, which are prepared by blending the highly refined base oils they produce in Mississauga with mixtures of antioxidants and other additives. Infineum is one of the world's leading formulators, manufacturers and marketers of fuel and lubricant additives, and supply PCL with additive packages used in their heavy duty diesel engine oils, passenger car motor oils and automatic transmission fluids. Infineum has the know-how and resources to translate discoveries made in the Pratt laboratory to products that can be incorporated into the next generation of PCL products, providing not only economic benefits to Canada, but also contributing to reduced consumption of fossil fuel-derived products here and around the world.