Translating Academic Discoveries in Radical-Trapping Antioxidant Chemistry to Commercial Technology Development

碳氢化合物自氧化是一个自发的过程，它限制了生物和从其衍生的化石燃料制成的产品的寿命。几乎所有碳氢化合物产品都添加了抗氧化剂，通过自氧化来减缓其降解速度。抗氧化剂的一个特别重要的应用是在发动机润滑油中。发动机运行期间，润滑油暴露在高温和高压下，极大地促进了它们的氧化降解。不断提高的燃油经济性标准和越来越多的人意识到我们必须最大限度地减少化石燃料的消耗，这就需要改进抗氧化剂技术，这一技术50年来基本上没有变化。渥太华大学普拉特实验室的令人兴奋的发现有可能满足这一需求。通过改进方法来评估测试配方中的有效性，这些发现将能够转化为商业产品，在测试配方中，可以快速识别和优化与其他润滑油成分的相互作用。同样，监测抗氧化剂在运行条件下的命运将为最大限度地延长抗氧化剂的寿命提供结构修改的见解。这项提议旨在验证化学工具，这些工具将使下一代抗氧化剂的开发成为可能。拟议中的与加拿大石油润滑油公司(PCL)和英飞凌国际公司(Infineum)的合作为翻译提供了理想的平台。PCL是加拿大最大的成品润滑油供应商，这些润滑油是通过将他们在密西索加生产的高度精炼的基础油与抗氧化剂和其他添加剂的混合物混合而成的。英飞凌是世界领先的燃油和润滑油添加剂配方商、制造商和营销商之一，向PCL供应用于重型柴油发动机油、乘用车机油和自动变速箱油的添加剂组合。英飞凌拥有技术诀窍和资源，可以将普拉特实验室的发现转化为可以整合到下一代PCL产品中的产品，不仅为加拿大带来经济利益，还为减少这里和世界各地化石燃料衍生产品的消耗做出了贡献。

Hydrocarbon autoxidation is a spontaneous process that limits the longevity of living matter and the products made from the fossil fuels that derive therefrom. Antioxidants are added to essentially all hydrocarbon-based products to slow their degradation via autoxidation. A particularly important application of antioxidants is in engine lubricants. The high-temperatures and pressures to which lubricants are exposed during engine operation greatly facilitates their oxidative degradation. Ever increasing fuel economy standards and growing awareness that we must minimize fossil fuel consumption necessitates improvements in antioxidant technology, which has remained largely unchanged for 50 years. Exciting discoveries in the Pratt laboratory at the University of Ottawa have the potential to address this need. Translation of these discoveries to commercial products would be enabled by improved methods to assess efficacy in test formulations where interactions with other lubricant components could be rapidly identified and optimized. Likewise, means to monitor the fate of the antioxidants under operating conditions would provide insights on structural modifications that maximize antioxidant lifetime. This proposal aims to validate chemical tools that will enable the development of the next generation of antioxidants. The proposed partnership with Petro-Canada Lubricants (PCL) and Infineum International (Infineum) provides the ideal platform for translation. PCL is Canada's largest supplier of finished lubricants, which are prepared by blending the highly refined base oils they produce in Mississauga with mixtures of antioxidants and other additives. Infineum is one of the world's leading formulators, manufacturers and marketers of fuel and lubricant additives, and supply PCL with additive packages used in their heavy duty diesel engine oils, passenger car motor oils and automatic transmission fluids. Infineum has the know-how and resources to translate discoveries made in the Pratt laboratory to products that can be incorporated into the next generation of PCL products, providing not only economic benefits to Canada, but also contributing to reduced consumption of fossil fuel-derived products here and around the world.