Commercialization of clinical grade extracellular vesicles isolated using tangential flow filtration

使用切向流过滤分离临床级细胞外囊泡的商业化

• 批准号: 571244-2022
• 负责人: Davis, Darryl
• 金额: $ 1.46万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729098
• 关键词: Commercialization; clinical; grade; extracellular; vesicles

The objective of this project is to explore the market potential of a novel extracellular vesicle manufacturing strategy. Recently, we have shown that extracellular vesicles isolated from heart derived cells prevents a malignant heart rhythm condition that occurs after cardiac surgery called atrial fibrillation. But given that our previous work used ultracentrifugation methods alone to isolate extracellular vesicles, serious concerns were raised regarding the potential for realistic commercial translation. To address this potential limitation, we transitioned our technology to a tangential flow filtration methodology. This system allows large volumes of biological fluids to be rapidly processed and extracellular vesicles isolated. In this proposal, we seek funding to train a student to do a market analysis to assess the potential uptake of this technology. With this training, we will carefully explore existing competitor technologies to best position our innovation in the marketplace. This analysis will enable our team to adjust our commercialization and development strategies to the industry and provide relevant skills to engage with potential customers and industry stakeholders. Ultimately, we anticipate this program will help us identify the appropriate path forward for our technology, assist with crafting a compelling pitch and developing a market assessment report.

该项目的目的是探索一种新的胞外囊泡制造策略的市场潜力。最近，我们已经证明，从心脏来源的细胞分离的细胞外小泡可以预防心脏手术后发生的一种称为心房颤动的恶性心律状况。但考虑到我们之前的工作仅使用超速离心法分离细胞外小泡，人们对现实商业翻译的可能性提出了严重的担忧。为了解决这一潜在限制，我们将我们的技术过渡到切向流过滤方法。该系统允许快速处理大量生物液，并分离细胞外小泡。在这项提案中，我们寻求资金来培训一名学生进行市场分析，以评估这项技术的潜在采用。通过此次培训，我们将仔细探索现有的竞争对手技术，以便在市场上最好地定位我们的创新。这一分析将使我们的团队能够根据行业调整我们的商业化和发展战略，并提供与潜在客户和行业利益相关者接触的相关技能。最终，我们预计该计划将帮助我们为我们的技术确定适当的前进道路，帮助我们制定令人信服的推销方案，并制定市场评估报告。